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Nilotinib (AMN-107)


Bcr-Abl 抑制剂

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产品目录号: A10644


产品名 目录号 价格 数量
Nilotinib (AMN-107) 100mg A10644-100
¥ 300.00
Nilotinib (AMN-107) 200mg A10644-200
¥ 500.00
Nilotinib (AMN-107) 10mM * 1mL in DMSO A10644-10mM-D
¥ 720.00



Nilotinib is a Bcr-Abl inhibitor with IC50 less than 30 nM.

Nilotinib (AMN-107)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Nilotinib (AMN-107) 发表的文献 (2)
  • Rami Shinnawi, .et al. Monitoring Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Genetically Encoded Calcium and Voltage Fluorescent Reporters, Stem Cell Reports, 2015, Oct 13; 5(4): 582每596 PMID: 26372632
  • Tetsuya Saita, .et al. Preparation of Antibodies and Development of an Enzyme-Linked Immunosorbent Assay for the Tyrosine Kinase Inhibitors Lapatinib and Nilotinib., Biol Pharm Bull. , 2015, 38(10):1652-7 PMID: 26424026

Chemical Information

目录号 A10644
Mechanism of action Inhibitor
分子量 529.5
化学分子式 C28H22F3N7O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 641571-10-0
Synonyms AMN107
SMILES code CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)N3C=C(N=C3)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CC=C5
化学名称 4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide


Nilotinib is a Bcr-Abl inhibitor with IC50 less than 30 nM.
Bcr-Abl (Murine myeloid progenitor cells)
<30 nM


Solubility (25°C) * In vitro DMSO 27 mg/mL (50.98 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.89 mL 94.43 mL 188.86mL
0.5 mM 3.78 mL 18.89 mL 37.77 mL
1 mM 1.89 mL 9.44 mL 18.89 mL
5 mM 0.38 mL 1.89 mL 3.78 mL

*The above data is based on the productmolecular weight 529.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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