Nivatrotamab (Hu3F8-BsAb) is a humanized bispecific antibody targeting both GD2 and CD3 antigens. This dual specificity enables Nivatrotamab to function as a T-cell engager, facilitating the direct interaction between T-cells and GD2-expressing tumor cells. It is primarily utilized in research focused on neuroblastoma, a cancer that commonly arises from neural crest cells in the adrenal glands and can also develop in nerve tissues throughout the body. Nivatrotamab's mechanism of action and its role in recruiting and activating T-cells against GD2-positive cancer cells make it a valuable tool in immuno-oncology research.
Nivatrotamab (Hu3F8-BsAb) is a humanized bispecific antibody targeting both GD2 and CD3 antigens. This dual specificity enables Nivatrotamab to function as a T-cell engager, facilitating the direct interaction between T-cells and GD2-expressing tumor cells. It is primarily utilized in research focused on neuroblastoma, a cancer that commonly arises from neural crest cells in the adrenal glands and can also develop in nerve tissues throughout the body. Nivatrotamab's mechanism of action and its role in recruiting and activating T-cells against GD2-positive cancer cells make it a valuable tool in immuno-oncology research.
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