产品详情

生物活性

NKL 22 is a HDAC inhibitor. The value of IC 50 is 78 uM NKL 22 increase frataxin protein concentrations NKL 22 inhibitors increase FXN mRNA in FRDA lymphocytes. HDAC inhibitors act directly on FXN.

溶解度 *

In vitro	DMSO	62 mg/mL (190.53 mM)
	Water	Insoluble
	Ethanol	3 mg/mL (9.21 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.73 mL	153.66 mL	307.31 mL
0.5 mM	6.15 mL	30.73 mL	61.46 mL
1 mM	3.07 mL	15.37 mL	30.73 mL
5 mM	0.61 mL	3.07 mL	6.15 mL

*The above data is based on the productmolecular weight 325.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A20600
M. Wt	325.4
Formula	C19H23N3O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	537034-15-4
Synonyms	NKL22, NKL-22
SMILES	O=C(NC1=CC=CC=C1N)CCCCCC(NC2=CC=CC=C2)=O