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NMS-1286937

PLK 抑制剂

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产品目录号: A13045

库存状态:中国现货中国现货

产品名 目录号 价格 数量
NMS-1286937 10mg A13045-10
¥ 1,200.00
NMS-1286937 25mg A13045-25
¥ 2,500.00
NMS-1286937 50mg A13045-50
¥ 4,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

NMS-1286937 is an orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity.

NMS-1286937

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Chemical Information

目录号 A13045
Mechanism of action Inhibitor
分子量 532.52
化学分子式 C24H27F3N8O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1034616-18-6
Synonyms NMS1286937, NMS-P937
SMILES code CN1CCN(CC1)C2=CC(=C(C=C2)OC(F)(F)F)NC3=NC=C4CCC5=C(C4=N3)N(N=C5C(=O)N)CCO
化学名称 4,5-dihydro-1-(2-hydroxyethyl)-8-[[5-(4-methyl-1-piperazinyl)-2-(trifluoromethoxy)phenyl]amino]-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

生物活性

Description
NMS-1286937 is an orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity.
Targets
PLK1 PLK2 PLK3
2 nM>10 μM>10 μM

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.78 mL 93.89 mL 187.79mL
0.5 mM 3.76 mL 18.78 mL 37.56 mL
1 mM 1.88 mL 9.39 mL 18.78 mL
5 mM 0.38 mL 1.88 mL 3.76 mL

*The above data is based on the productmolecular weight 532.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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