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Nocodazole是微管抑制剂；抑制有丝分裂。也抑制自噬体-溶酶体融合。
靶点信息
| Microtubules (Cell-free assay) | Abl (Cell-free assay) | Abl (E255K) (Cell-free assay) | Abl (T315I) (Cell-free assay) | |
| N/A | 0.21 μM | 0.53 μM | 0.64 μM |
| In vitro (25°C) | DMSO | 6 mg/mL (19.91 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 2% DMSO+30% PEG 300+2% Tween 80+ddH2O | 1 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 33.19 mL | 165.94 mL | 331.87 mL |
| 0.5 mM | 6.64 mL | 33.19 mL | 66.37 mL |
| 1 mM | 3.32 mL | 16.59 mL | 33.19 mL |
| 5 mM | 0.66 mL | 3.32 mL | 6.64 mL |
*The above data is based on the productmolecular weight 301.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13219 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 301.32 |
| Formula | C14H11N3O3S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 31430-18-9 |
| SMILES | COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CS3 |
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