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NPI-2358 (Plinabulin)

促销

Microtubule 抑制剂

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产品目录号: A10654

库存状态:中国现货中国现货

产品名 目录号 价格 数量
NPI-2358 5mg A10654-5
¥ 600.00
NPI-2358 10mg A10654-10
¥ 1,000.00
NPI-2358 50mg A10654-50
¥ 3,000.00
NPI-2358 100mg A10654-100
¥ 5,000.00
NPI-2358 (Plinabulin) 10mM * 1mL in DMSO A10654-10mM-D
¥ 990.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

NPI-2358 is a synthetic analog of NPI-2350, a natural product isolated from Aspergillus sp., which depolymerizes microtubules in A549 human lung carcinoma cells.

NPI-2358 (Plinabulin)

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Chemical Information

目录号 A10654
Mechanism of action Inhibitor
分子量 336.4
化学分子式 C19H20N4O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 714272-27-2
Synonyms NPI2358
SMILES code CC(C)(C)C1=C(N=CN1)/C=C\2/C(=O)N/C(=C\C3=CC=CC=C3)/C(=O)N2
化学名称 (3E,6E)-3-benzylidene-6-((5-(tert-butyl)-1H-imidazol-4-yl)methylene)piperazine-2,5-dione

生物活性

Description
NPI-2358 is a synthetic analog of NPI-2350, a natural product isolated from Aspergillus sp., which depolymerizes microtubules in A549 human lung carcinoma cells.
Targets
Tubulin
9.8 nM-18 nM

溶解性

Solubility (25°C)* In vitro DMSO 54 mg/mL heating (160.52 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.73 mL 148.63 mL 297.27mL
0.5 mM 5.95 mL 29.73 mL 59.45 mL
1 mM 2.97 mL 14.86 mL 29.73 mL
5 mM 0.59 mL 2.97 mL 5.95 mL

*The above data is based on the productmolecular weight 336.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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