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NSC-207895 (XI-006)

MDMX 抑制剂

158 Customer Reviews
产品目录号: A11179

库存状态:中国现货中国现货

产品名 目录号 价格 数量
NSC-207895 5mg A11179-5
¥ 900.00
NSC-207895 10mg A11179-10
¥ 1,600.00
NSC-207895 50mg A11179-50
¥ 7,000.00
NSC-207895 100mg A11179-100
¥ 12,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

NSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation.

NSC-207895 (XI-006)

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Chemical Information

目录号 A11179
Mechanism of action Inhibitor
分子量 279.25
化学分子式 C11H13N5O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 58131-57-0
Synonyms NSC207895
SMILES code CN1CCN(CC1)C2=CC=C(C3=NO[N+](=C23)[O-])[N+](=O)[O-]
化学名称 4-(4-Methyl-1-piperazinyl)-7-nitrobenzofurazane 3-oxide

生物活性

Description

NSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation.

Targets
p53 MDMX
N/A2.5 μM

溶解性

Solubility (25°C)* In vitro DMSO 0.4 mg/mL (1.43 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 35.81 mL 179.05 mL 358.1mL
0.5 mM 7.16 mL 35.81 mL 71.62 mL
1 mM 3.58 mL 17.91 mL 35.81 mL
5 mM 0.72 mL 3.58 mL 7.16 mL

*The above data is based on the productmolecular weight 279.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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