NSC-207895 (XI-006)

目录号: A11179

MDMX Inhibitor

NSC-207895 (XI-006) Chemical Structure

CAS NO. 58131-57-0

NSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation.

库存: 现货

规格 价格 数量
5 mg
¥ 900.00
10 mg
¥ 1,600.00
50 mg
¥ 7,000.00
100 mg
¥ 12,000.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

NSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation.

Targets
p53 MDMX
N/A2.5 μM
In vitro DMSO 0.4 mg/mL (1.43 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 35.81 mL 179.05 mL 358.1 mL
0.5 mM 7.16 mL 35.81 mL 71.62 mL
1 mM 3.58 mL 17.91 mL 35.81 mL
5 mM 0.72 mL 3.58 mL 7.16 mL

*The above data is based on the productmolecular weight 279.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11179
MECHANISM OF ACTION Inhibitor
M. Wt 279.25
Formula C11H13N5O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 58131-57-0
Synonyms NSC207895
SMILES CN1CCN(CC1)C2=CC=C(C3=NO[N+](=C23)[O-])[N+](=O)[O-]

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