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NSC348884

nucleophosmin 抑制剂

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产品目录号: A13117

库存状态:中国现货中国现货

产品名 目录号 价格 数量
NSC348884 5mg A13117-5
¥ 800.00
NSC348884 10mg A13117-10
¥ 1,500.00
NSC348884 25mg A13117-25
¥ 2,500.00
NSC348884 50mg A13117-50
¥ 4,500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

NSC348884 is a nucleolar phosphoprotein that displays several biological activities in ribosome biogenesis, cell proliferation, cytoplasmic/nuclear shuttle transportation, nucleic acid binding, ribonucleic cleavage, and centrosome duplication. NSC 348884 is a putative inhibitor of nucleophosmin (NPM). NSC 348884 inhibits NMP oligomer formation, up-regulates p53 and induces apoptosis.

NSC348884

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Chemical Information

目录号 A13117
Mechanism of action Inhibitor
分子量 636.79
化学分子式 C38H40N10
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 81624-55-7
Synonyms NSC 348884, NSC-348884
SMILES code CC1=CC2=C(C=C1)N=C(N2)CN(CCN(CC3=NC4=C(N3)C=C(C=C4)C)CC5=NC6=C(N5)C=C(C=C6)C)CC7=NC8=C(N7)C=C(C=C8)C
化学名称 N1,N1,N2,N2-Tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]-1,2-ethanediamine

生物活性

Description
NSC348884 is a nucleolar phosphoprotein that displays several biological activities in ribosome biogenesis, cell proliferation, cytoplasmic/nuclear shuttle transportation, nucleic acid binding, ribonucleic cleavage, and centrosome duplication. NSC 348884 is a putative inhibitor of nucleophosmin (NPM). NSC 348884 inhibits NMP oligomer formation, up-regulates p53 and induces apoptosis.
Targets
nucleophosmin

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.7 mL 78.52 mL 157.04mL
0.5 mM 3.14 mL 15.7 mL 31.41 mL
1 mM 1.57 mL 7.85 mL 15.7 mL
5 mM 0.31 mL 1.57 mL 3.14 mL

*The above data is based on the productmolecular weight 636.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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