产品详情

生物活性

NSC-87877是SHP-1和SHP-2的细胞可渗透抑制剂，IC50值分别为355和318 nM。

靶点信息

SHP-2	SHP-1
318 nM	355 nM

溶解度 *

In vitro (25°C)	DMSO	85 mg/mL (168.84 mM)
	Water	85 mg/mL (168.84 mM)
	Ethanol	Insoluble
In vivo	2% DMSO+35% PEG 300+2% Tween 80+ddH2O	5 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.86 mL	99.32 mL	198.64 mL
0.5 mM	3.97 mL	19.86 mL	39.73 mL
1 mM	1.99 mL	9.93 mL	19.86 mL
5 mM	0.4 mL	1.99 mL	3.97 mL

*The above data is based on the productmolecular weight 503.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A16120
作用机制	Inhibitor (抑制剂)
M. Wt	503.42
Formula	C19H13N3O7S2.2Na
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	56932-43-5
Synonyms	NSC-87877, NSC 87877
SMILES	C1=CC2=C(C(=O)C(=NNC3=CC4=C(C=C3)C=C(C=C4)S(=O)(=O)[O-])C=C2S(=O)(=O)[O-])N=C1.[Na+].[Na+]