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NU-7441 (KU-57788)


DNA-PK 抑制剂

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产品目录号: A11098


产品名 目录号 价格 数量
NU-7441 (KU-57788) 5mg A11098-5
¥ 500.00
NU-7441 (KU-57788) 10mg A11098-10
¥ 900.00
NU-7441 (KU-57788) 50mg A11098-50
¥ 1,800.00
NU-7441 (KU-57788) 100mg A11098-100
¥ 3,000.00



NU-7441 (KU-57788) is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor. The IC50 values are 14, 1700, 5000, >100000 and >100000 nM for DNA-PK, mTOR, PI 3-K, ATM and ATR respectively.

NU-7441 (KU-57788)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 NU-7441 (KU-57788) 发表的文献 (4)
  • Shahar Biechonski, .et al. Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation, Sci Rep, 2018, Apr 17 PMID: 29666389
  • Ihara M, .et al. Expression of the DNA-dependent protein kinase catalytic subunit is associated with the radiosensitivity of human thyroid cancer cell lines, J Radiat Res, 2018, Nov 23 PMID: 30476230
  • Chwastek J, .et al. The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a 污H2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D, Int J Biochem Cell Biol, 2017, Jun;87:38-53 PMID: 28341201
  • Masaaki Yanai, .et al. DNA-PK Inhibition by NU7441 Enhances Chemosensitivity to Topoisomerase Inhibitor in Non-Small Cell Lung Carcinoma Cells by Blocking DNA Damage Repair, Yonago Acta Med, 2017, Mar; 60(1): 9每15 PMID: 28331416

Chemical Information

目录号 A11098
Mechanism of action Inhibitor
分子量 413.5
化学分子式 C25H19NO3S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 503468-95-9
Synonyms NU7441, KU57788
化学名称 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one


NU-7441 (KU-57788) is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor. The IC50 values are 14, 1700, 5000, >100000 and >100000 nM for DNA-PK, mTOR, PI 3-K, ATM and ATR respectively.


Solubility (25°C)* In vitro DMSO 3 mg/mL (7.25 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.18 mL 120.92 mL 241.84mL
0.5 mM 4.84 mL 24.18 mL 48.37 mL
1 mM 2.42 mL 12.09 mL 24.18 mL
5 mM 0.48 mL 2.42 mL 4.84 mL

*The above data is based on the productmolecular weight 413.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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