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NU7026

促销

DNA-PK 抑制剂

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产品目录号: A12752

库存状态:中国现货中国现货

产品名 目录号 价格 数量
NU7026 10mg A12752-10
¥ 500.00
NU7026 25mg A12752-25
¥ 1,000.00
NU7026 50mg A12752-50
¥ 1,600.00
NU7026 100mg A12752-100
¥ 2,800.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

NU7026 is a novel DNA-dependent protein kinase inhibitor that potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia.

NU7026

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Chemical Information

目录号 A12752
Mechanism of action Inhibitor
分子量 281.31
化学分子式 C17H15NO3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 154447-35-5
Synonyms NU 7026, NU-7026
SMILES code C1COCCN1C2=CC(=O)C3=C(O2)C4=CC=CC=C4C=C3
化学名称 2-(Morpholin-4-yl)-benzo[h]chromen-4-one

生物活性

Description
NU7026 is a novel DNA-dependent protein kinase inhibitor that potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia.
Targets
DNA-PK (Cell-free assay) PI3K (Cell-free assay) ATM (Cell-free assay) ATR (Cell-free assay)
0.23 μM13 μM>100 μM>100 μM

溶解性

Solubility (25°C) * In vitro DMSO 1 mg/mL (3.55 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 35.55 mL 177.74 mL 355.48mL
0.5 mM 7.11 mL 35.55 mL 71.1 mL
1 mM 3.55 mL 17.77 mL 35.55 mL
5 mM 0.71 mL 3.55 mL 7.11 mL

*The above data is based on the productmolecular weight 281.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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