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Nutlin-3

促销

Mdm2 拮抗剂

158 Customer Reviews
产品目录号: A10657

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Nutlin-3 5mg A10657-5
¥ 650.00
Nutlin-3 25mg A10657-25
¥ 2,000.00
Nutlin-3 50mg A10657-50
¥ 3,600.00
Nutlin-3 100mg A10657-100
¥ 5,600.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

MDM2 antagonist nutlin-3 is a potent inducer of apoptosis.

Nutlin-3

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Nutlin-3 发表的文献 (4)
  • Maxime Parisotto, .et al. PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo, J Exp Med, 2018, Jun 4; 215(6): 1749每1763 PMID: 29743291
  • Ohmuro-Matsuyama Y, .et al. Evaluation of protein-ligand interactions using the luminescent interaction assay FlimPIA with streptavidin-biotin linkage, Anal Biochem, 2018, Dec 15;563:61-66 PMID: 30316750
  • Alisa A. Garaeva, .et al. Mitochondrial dysfunction induces SESN2 gene expression through Activating Transcription Factor 4, Cell Cycle, 2016, 15(1): 64每71 PMID: 26771712
  • A G Evstafieva, .et al. A sustained deficiency of mitochondrial respiratory complex III induces an apoptotic cell death through the p53-mediated inhibition of pro-survival activities of the activating transcription factor 4, Cell Death Dis., 2014, 5(11): e1511. PMID: 25375376

Chemical Information

目录号 A10657
Mechanism of action Antagonist
分子量 581.5
化学分子式 C30H30Cl2N4O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 548472-68-0
Synonyms Nutlin3
SMILES code CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
化学名称 4-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one

生物活性

Description
MDM2 antagonist nutlin-3 is a potent inducer of apoptosis.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.2 mL 85.98 mL 171.97mL
0.5 mM 3.44 mL 17.2 mL 34.39 mL
1 mM 1.72 mL 8.6 mL 17.2 mL
5 mM 0.34 mL 1.72 mL 3.44 mL

*The above data is based on the productmolecular weight 581.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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