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Nutlin 3a

促销

MDM2 抑制剂

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产品目录号: A11501

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Nutlin 3a 5mg A11501-5
¥ 700.00
Nutlin 3a 10mg A11501-10
¥ 1,200.00
Nutlin 3a 25mg A11501-25
¥ 2,200.00
Nutlin 3a 50mg A11501-50
¥ 3,800.00
Nutlin 3a 10mM * 1mL in DMSO A11501-10mM-D
¥ 1,400.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Nutlin 3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53.

Nutlin 3a

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Nutlin 3a 发表的文献 (1)
  • Momoko Ishimine, .et al. The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer, Dis Markers, 2018, 2018: 5280736 PMID: 29651325

Chemical Information

目录号 A11501
Mechanism of action Inhibitor
分子量 581.49
化学分子式 C30H30Cl2N4O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 675576-98-4
Synonyms Nutlin-3a, (-)-Nutlin-3
SMILES code CC(C)OC1=C(C=CC(=C1)OC)C2=N[C@H]([C@H](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
化学名称 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl]carbonyl]piperazin-2-one

生物活性

Description
Nutlin 3a is a potent inhibitor of MDM2 (mouse double minute 2) binding to p53 that induces the expression of p53 regulated genes, and shows potent antiproliferative activity in cells expressing functional p53.
Targets
p53/MDM2 interaction (Cell-free assay)
90 nM

溶解性

Solubility (25°C) * In vitro DMSO 100 mg/mL (171.97 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (171.97 mM)
In vivo 2% DMSO/1% hydroxyethyl cellulose/0.2% Tween 80 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.2 mL 85.99 mL 171.97mL
0.5 mM 3.44 mL 17.2 mL 34.39 mL
1 mM 1.72 mL 8.6 mL 17.2 mL
5 mM 0.34 mL 1.72 mL 3.44 mL

*The above data is based on the productmolecular weight 581.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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