Nutlin 3b
目录号: A11502
MDM2 抑制剂
Nutlin 3b 是一种 p53/MDM2 对抗剂或抑制剂，其 IC50 值为 13.6 uM，与相反的 (-)-对映体 Nutlin-3a 相比，其效力低 150 倍，是 Nutlin-3 的较弱的 (+)-对映体。
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生物活性
| Discription | Nutlin 3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 uM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a. | |||||
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| Cell Research |
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产品信息
| 目录号 | A11502 |
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| 分子式 | C30H30Cl2N4O4 |
| 分子量 | 581.49 |
| CAS号 | 675576-97-3 |
| SMILES | CC(C)OC1=C(C=CC(=C1)OC)C2=N[C@@H]([C@@H](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl |
| 其他名称 | (+)-Nutlin-3, Nutlin-3b |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 90 mg/mL (154.77 mM) | |
| Water | Insoluble | ||
| Ethanol | 90 mg/mL (154.77 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.2 mL | 85.99 mL | 171.97 mL |
| 0.5 mM | 3.44 mL | 17.2 mL | 34.39 mL |
| 1 mM | 1.72 mL | 8.6 mL | 17.2 mL |
| 5 mM | 0.34 mL | 1.72 mL | 3.44 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 675576-97-3 | 675576-97-3 供应商 | 675576-97-3 花费 | 675576-97-3 生产商 | 订购 675576-97-3 | 675576-97-3 代理商