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NVP-ADW742

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IGF-1R 抑制剂

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产品目录号: A10658

库存状态:中国现货中国现货

产品名 目录号 价格 数量
NVP-ADW742 5mg A10658-5
¥ 1,100.00
NVP-ADW742 10mg A10658-10
¥ 1,900.00
NVP-ADW742 50mg A10658-50
¥ 6,600.00
NVP-ADW742 100mg A10658-100
¥ 12,500.00
NVP-ADW742 10mM * 1mL in DMSO A10658-10mM-D
¥ 1,200.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM.

NVP-ADW742

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 NVP-ADW742 发表的文献 (2)
  • Kazuya Takayama, .et al. Leucine/glutamine and v-ATPase/lysosomal acidification via mTORC1 activation are required for position-dependent regeneration, Sci Rep, 2018, 8: 8278 PMID: 29844341
  • Kentaro Hirose, .et al. Mechanistic target of rapamycin complex 1 signaling regulates cell proliferation, cell survival, and differentiation in regenerating zebrafish fins, BMC Dev Biol, 2014, 14: 42. PMID: 25480380

Chemical Information

目录号 A10658
Mechanism of action Inhibitor
分子量 453.6
化学分子式 C28H31N5O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 475488-23-4
Synonyms NVPADW742, ADW742, ADW-742, GSK 552602A
SMILES code C1CCN(C1)CC2CC(C2)N3C=C(C4=C3N=CN=C4N)C5=CC(=CC=C5)OCC6=CC=CC=C6
化学名称 5-(3-Benzyloxyphenyl)-7-[trans-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

生物活性

Description
NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM.
Targets
IGF-1R
0.17 μM

溶解性

Solubility (25°C)* In vitro DMSO 10 mg/mL heating (22.04 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (6.61 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.05 mL 110.23 mL 220.46mL
0.5 mM 4.41 mL 22.05 mL 44.09 mL
1 mM 2.2 mL 11.02 mL 22.05 mL
5 mM 0.44 mL 2.2 mL 4.41 mL

*The above data is based on the productmolecular weight 453.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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