NVP-AEW541

目录号: A11021

IGF-1R inhibitor

NVP-AEW541

NVP-AEW541 Chemical Structure

CAS NO. 475489-16-8

NVP-AEW541 is a selective IGF-1R kinase inhibitor that inhibits the autophosphorylation activity of IGF-1R (IC50 = 0.086 uM) and prevents IGF-1-mediated survival and proliferation of MCF-7 cells (IC50 = 0.16 and 1.64 uM, respectively).

库存: 现货

规格 价格 数量
2 mg
¥ 800.00
5 mg
¥ 1,200.00
10 mg
¥ 1,500.00
25 mg
¥ 3,000.00
10mM * 1mL in DMSO
¥ 1,100.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

NVP-AEW541 is a selective IGF-1R kinase inhibitor that inhibits the autophosphorylation activity of IGF-1R (IC50 = 0.086 uM) and prevents IGF-1-mediated survival and proliferation of MCF-7 cells (IC50 = 0.16 and 1.64 uM, respectively).
In vitro (25°C) DMSO 88 mg/mL (200.2 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.75 mL 113.74 mL 227.48 mL
0.5 mM 4.55 mL 22.75 mL 45.5 mL
1 mM 2.27 mL 11.37 mL 22.75 mL
5 mM 0.45 mL 2.27 mL 4.55 mL

*The above data is based on the productmolecular weight 439.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A11021
MECHANISM OF ACTION Inhibitor
M. Wt 439.6
Formula C27H29N5O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 475489-16-8
Synonyms AEW541
SMILES C1CN(C1)CC2CC(C2)N3C=C(C4=C3N=CN=C4N)C5=CC(=CC=C5)OCC6=CC=CC=C6

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