Trusted by 10,000+ Scientists since 2006
微信关注
申请试用装

NVP-AEW541

促销

IGF-1R 抑制剂

0 Customer Reviews
产品目录号: A11021

库存状态:中国现货中国现货

产品名 目录号 价格 数量
NVP-AEW541 2mg A11021-2
¥ 800.00
NVP-AEW541 5mg A11021-5
¥ 1,200.00
NVP-AEW541 10mg A11021-10
¥ 1,500.00
NVP-AEW541 25mg A11021-25
¥ 3,000.00
NVP-AEW541 10mM * 1mL in DMSO A11021-10mM-D
¥ 1,100.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

NVP-AEW541 is a selective IGF-1R kinase inhibitor that inhibits the autophosphorylation activity of IGF-1R (IC50 = 0.086 uM) and prevents IGF-1-mediated survival and proliferation of MCF-7 cells (IC50 = 0.16 and 1.64 uM, respectively).

NVP-AEW541

双击上述图片即可查看完整大小

缩小
放大

更多视图

顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 NVP-AEW541 发表的文献 (1)
  • Tsushima H, .et al. Kinase inhibitors of the IGF-1R as a potential therapeutic agent for rheumatoid arthritis, Autoimmunity, 2017, Aug;50(5):329-335 PMID: 28682648

Chemical Information

目录号 A11021
Mechanism of action Inhibitor
分子量 439.6
化学分子式 C27H29N5O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 475489-16-8
Synonyms AEW541
SMILES code C1CN(C1)CC2CC(C2)N3C=C(C4=C3N=CN=C4N)C5=CC(=CC=C5)OCC6=CC=CC=C6
化学名称 7-​[cis-​3-​(1-​azetidinylmethyl)cyclobutyl]-​5-​[3-​(phenylmethoxy)phenyl]-​7H-​pyrrolo[2,​3-​d]pyrimidin-​4-​amine

生物活性

Description
NVP-AEW541 is a selective IGF-1R kinase inhibitor that inhibits the autophosphorylation activity of IGF-1R (IC50 = 0.086 uM) and prevents IGF-1-mediated survival and proliferation of MCF-7 cells (IC50 = 0.16 and 1.64 uM, respectively).

溶解性

Solubility (25°C) * In vitro DMSO 88 mg/mL (200.2 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.75 mL 113.74 mL 227.48mL
0.5 mM 4.55 mL 22.75 mL 45.5 mL
1 mM 2.27 mL 11.37 mL 22.75 mL
5 mM 0.45 mL 2.27 mL 4.55 mL

*The above data is based on the productmolecular weight 439.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

产品标签

使用空格分隔标签。使用单引号(')标注词组。

Similar product(s)


Keywords:购买 NVP-AEW541 | NVP-AEW541 供应商 | 订购 NVP-AEW541 | NVP-AEW541 价格 | NVP-AEW541 生产商 | 订单 NVP-AEW541 | NVP-AEW541 代理商 | 购买 475489-16-8| 475489-16-8 供应商 | 订购 475489-16-8 | 475489-16-8 价格 | 475489-16-8 生产商 | 订单 475489-16-8 | 475489-16-8 代理商|buy NVP-AEW541 | NVP-AEW541 Supplier | purchase NVP-AEW541 | NVP-AEW541 cost | NVP-AEW541 manufacturer | order NVP-AEW541 | NVP-AEW541 distributor | buy 475489-16-8| 475489-16-8 Supplier | purchase 475489-16-8 | 475489-16-8 cost | 475489-16-8 manufacturer | order 475489-16-8 | 475489-16-8 distributor