NVP-AEW541

Name: NVP-AEW541
SKU: A11021
Price: 245 CNY
Rating: 5 (3 reviews)

目录号: A11021

IGF-1R 抑制剂

3 篇发表文献

NVP-AEW541 是一种选择性的 IGF-1R 激酶抑制剂，能够抑制 IGF-1R 的自磷酸化活性（IC50 = 0.086 uM），并阻止 IGF-1介导的 MCF-7 细胞的存活和增殖（IC50 分别为 0.16 和 1.64 uM）。

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Grouped product items
规格	价格	库存
1mg	¥245.00	现货
2mg	¥350.00	现货
5mg	¥595.00	现货
10mg	¥1,015.00	现货
25mg	¥1,855.00	现货
50mg	¥3,675.00	现货
100mg	¥5,530.00	现货
*10mM 1mL in DMSO**	¥595.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用NVP-AEW541发表的3篇文献

Deep R Sharma, .et al. , Cereb Cortex, 2023, Jan 16 PMID: 36646459

Ashalyn P Watt, .et al. , Cell Tissue Res, 2021, Jan 13 PMID: 33439347

Tsushima H, .et al. , Autoimmunity, 2017, Aug;50(5):329-335 PMID: 28682648

生物活性

Discription

NVP-AEW541 is a selective IGF-1R kinase inhibitor that inhibits the autophosphorylation activity of IGF-1R (IC50 = 0.086 uM) and prevents IGF-1-mediated survival and proliferation of MCF-7 cells (IC50 = 0.16 and 1.64 uM, respectively).

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11021
分子式	C27H29N5O
分子量	439.6
CAS号	475489-16-8
SMILES	C1CN(C1)CC2CC(C2)N3C=C(C4=C3N=CN=C4N)C5=CC(=CC=C5)OCC6=CC=CC=C6
其他名称	AEW541
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	77 mg/mL (175.18 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	19 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.75 mL	113.74 mL	227.48 mL
0.5 mM	4.55 mL	22.75 mL	45.5 mL
1 mM	2.27 mL	11.37 mL	22.75 mL
5 mM	0.45 mL	2.27 mL	4.55 mL

Useful Calculator

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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