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NVP-BAW2881

促销

VEGFR 抑制剂

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产品目录号: A12693

库存状态:中国现货中国现货

产品名 目录号 价格 数量
NVP-BAW2881 5mg A12693-5
¥ 900.00
NVP-BAW2881 10mg A12693-10
¥ 1,800.00
NVP-BAW2881 25mg A12693-25
¥ 3,400.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

NVP-BAW2881 is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit chronic and acute skin inflammation.

NVP-BAW2881

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Chemical Information

目录号 A12693
Mechanism of action Inhibitor
分子量 424.1147
化学分子式 C22H15F3N4O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 861875-60-7
Synonyms BAW2881, BAW-2881, BAW 2881, NVP-BAW-2881, NVP-BAW 2881
SMILES code O=C(NC1=CC(C(F)(F)F)=CC=C1)C2=CC=CC3=C2C=CC(OC4=CC=NC(N)=N4)=C3
化学名称 6-((2-aminopyrimidin-4-yl)oxy)-N-(3-(trifluoromethyl)phenyl)-1-naphthamide

生物活性

Description
NVP-BAW2881 is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit chronic and acute skin inflammation.
Targets
Target Value
TIE-2
hVEGFR2IC50: 9nM
C-Raf-1IC50: 24nM
B-RAFV599EIC50: 76nM
c-AblIC50: 99nM
mVEGF2IC50: 165nM
RETIC50: 410nM
hVEGFR3IC50: 420nM
hVEGFR1IC50: 820nM
c-KITIC50: 2.5μM

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.58 mL 117.89 mL 235.79mL
0.5 mM 4.72 mL 23.58 mL 47.16 mL
1 mM 2.36 mL 11.79 mL 23.58 mL
5 mM 0.47 mL 2.36 mL 4.72 mL

*The above data is based on the productmolecular weight 424.1147. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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