|Mechanism of action||Inhibitor|
|储存方式||at -20°C 2 years|
|Synonyms||NVPBGT226, BGT226, BGT-226|
|化学名称||1-(3-(Trifluoromethyl)-4-(piperazin-1-yl)phenyl)-8-(6-methoxypyridin-3-yl)-3-methyl-1H-imidazo[4,5-c]quinolin-2(3H)-one maleic acid salt|
NVP-BGT226, novel phosphoinositide 3-kinase/mTOR dual inhibitor, displays potent growth-inhibitory activity against human head and neck cancer cells in vitro and in vivo.
|Solubility (25°C) *||In vitro||DMSO||30 mg/mL (46.11 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||<1 mg/mL (<1 mM)|
|In vivo||30% PEG400/0.5% Tween80/5% propylene glycol||30 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||15.37 mL||76.85 mL||153.7mL|
|0.5 mM||3.07 mL||15.37 mL||30.74 mL|
|1 mM||1.54 mL||7.69 mL||15.37 mL|
|5 mM||0.31 mL||1.54 mL||3.07 mL|
*The above data is based on the productmolecular weight 650.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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