产品详情

生物活性

NVP-BGT226，新型磷酸肌醇3-激酶/mTOR双重抑制剂，作用于PI3Kα/β/γ，IC50为4 nM/63 nM/38 nM，在体外和体内对人的头颈癌细胞均显示出强大的生长抑制活性。

靶点信息

mTOR	PI3Kα	PI3Kγ	PI3Kβ
N/A	4 nM	38 nM	63 nM

溶解度 *

In vitro (25°C)	DMSO	27 mg/mL (41.5 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.37 mL	76.85 mL	153.7 mL
0.5 mM	3.07 mL	15.37 mL	30.74 mL
1 mM	1.54 mL	7.69 mL	15.37 mL
5 mM	0.31 mL	1.54 mL	3.07 mL

*The above data is based on the productmolecular weight 650.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11162
作用机制	Inhibitor (抑制剂)
M. Wt	650.6
Formula	C28H25F3N6O2.C4H4O4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1245537-68-1
Synonyms	NVPBGT226, BGT226, BGT-226
SMILES	CN1C2=CN=C3C=CC(=CC3=C2N(C1=O)C4=CC(=C(C=C4)N5CCNCC5)C(F)(F)F)C6=CN=C(C=C6)OC.C(=C\C(=O)O)\C(=O)O