NVP-BGT226

目录号: A11162

PI3K inhibitor

NVP-BGT226 Chemical Structure

CAS NO. 1245537-68-1

NVP-BGT226, novel phosphoinositide 3-kinase/mTOR dual inhibitor, displays potent growth-inhibitory activity against human head and neck cancer cells in vitro and in vivo.

库存: 现货

规格 价格 数量
5 mg
¥ 1,200.00
10 mg
¥ 2,050.00
50 mg
¥ 6,500.00
200 mg
¥ 18,000.00
10mM * 1mL in DMSO
¥ 2,000.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

NVP-BGT226, novel phosphoinositide 3-kinase/mTOR dual inhibitor, displays potent growth-inhibitory activity against human head and neck cancer cells in vitro and in vivo.

Targets
mTOR PI3Kα PI3Kγ PI3Kβ
N/A4 nM38 nM63 nM
In vitro (25°C) DMSO 30 mg/mL (46.11 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.37 mL 76.85 mL 153.7 mL
0.5 mM 3.07 mL 15.37 mL 30.74 mL
1 mM 1.54 mL 7.69 mL 15.37 mL
5 mM 0.31 mL 1.54 mL 3.07 mL

*The above data is based on the productmolecular weight 650.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11162
MECHANISM OF ACTION Inhibitor
M. Wt 650.6
Formula C28H25F3N6O2.C4H4O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1245537-68-1
Synonyms NVPBGT226, BGT226, BGT-226
SMILES CN1C2=CN=C3C=CC(=CC3=C2N(C1=O)C4=CC(=C(C=C4)N5CCNCC5)C(F)(F)F)C6=CN=C(C=C6)OC.C(=C\C(=O)O)\C(=O)O

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