NVP-BHG712

目录号: A10661

EphB4 inhibitor

NVP-BHG712

NVP-BHG712 Chemical Structure

CAS NO. 940310-85-0

NVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3.

库存: 现货

规格 价格 数量
5 mg
¥ 800.00
10 mg
¥ 1,500.00
50 mg
¥ 7,000.00
100 mg
¥ 12,000.00
10mM * 1mL in DMSO
¥ 1,400.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

NVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3.
Targets
Target Value
EphB4ED5025nM
C-RafIC50: 0.395μM
c-SrcIC50: 1.266μM
c-AblIC50: 1.667μM
Tie-2IC50: >10μM
AxlIC50: >10μM
HER1IC50: >10μM
PKAIC50: >10μM
CDK1IC50: >10μM
PKBIC50: >10μM
PDK-1IC50: >10μM
FGFR3IC50: >10μM
c-MetIC50: >10μM
In vitro (25°C) DMSO 101 mg/mL (200.6 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (5.95 mM)
In vivo NMP/polyethylene glycol 300 (10/90, v/v) 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.86 mL 99.3 mL 198.61 mL
0.5 mM 3.97 mL 19.86 mL 39.72 mL
1 mM 1.99 mL 9.93 mL 19.86 mL
5 mM 0.4 mL 1.99 mL 3.97 mL

*The above data is based on the productmolecular weight 503.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A10661
MECHANISM OF ACTION Inhibitor
M. Wt 503.5
Formula C26H20F3N7O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 940310-85-0
Synonyms NVPBHG712
SMILES CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NC3=NC(=NC4=C3C=NN4C)C5=CN=CC=C5

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