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NVP-BHG712

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EphB4 抑制剂

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产品目录号: A10661

库存状态:中国现货中国现货

产品名 目录号 价格 数量
NVP-BHG712 5mg A10661-5
¥ 800.00
NVP-BHG712 10mg A10661-10
¥ 1,500.00
NVP-BHG712 50mg A10661-50
¥ 7,000.00
NVP-BHG712 100mg A10661-100
¥ 12,000.00
NVP-BHG712 10mM * 1mL in DMSO A10661-10mM-D
¥ 1,400.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

NVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3.

NVP-BHG712

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 NVP-BHG712 发表的文献 (1)
  • Y Kaibori, .et al. EphA2 phosphorylation at Ser897 by the Cdk1/MEK/ERK/RSK pathway regulates M-phase progression via maintenance of cortical rigidity, the FASEB Journal, 2019, Jan 22:fj201801519RR PMID: 30668924

Chemical Information

目录号 A10661
Mechanism of action Inhibitor
分子量 503.5
化学分子式 C26H20F3N7O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 940310-85-0
Synonyms NVPBHG712
SMILES code CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NC3=NC(=NC4=C3C=NN4C)C5=CN=CC=C5
化学名称 4-Methyl-3-[[1-methyl-6-(3-pyridiny l)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(t rifluoromethyl)phenyl]benzamide trifluoroacetate

生物活性

Description
NVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3.
Targets
Target Value
EphB4ED5025nM
C-RafIC50: 0.395μM
c-SrcIC50: 1.266μM
c-AblIC50: 1.667μM
Tie-2IC50: >10μM
AxlIC50: >10μM
HER1IC50: >10μM
PKAIC50: >10μM
CDK1IC50: >10μM
PKBIC50: >10μM
PDK-1IC50: >10μM
FGFR3IC50: >10μM
c-MetIC50: >10μM

溶解性

Solubility (25°C) * In vitro DMSO 101 mg/mL (200.6 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (5.95 mM)
In vivo NMP/polyethylene glycol 300 (10/90, v/v) 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.86 mL 99.3 mL 198.61mL
0.5 mM 3.97 mL 19.86 mL 39.72 mL
1 mM 1.99 mL 9.93 mL 19.86 mL
5 mM 0.4 mL 1.99 mL 3.97 mL

*The above data is based on the productmolecular weight 503.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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