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NVP-BSK805

促销

JAK 抑制剂

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产品目录号: A11193

库存状态:中国现货中国现货

产品名 目录号 价格 数量
NVP-BSK805 5mg A11193-5
¥ 1,400.00
NVP-BSK805 10mg A11193-10
¥ 2,000.00
NVP-BSK805 50mg A11193-50
¥ 5,800.00
NVP-BSK805 100mg A11193-100
¥ 9,200.00
NVP-BSK805 10mM * 1mL in DMSO A11193-10mM-D
¥ 2,170.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

NVP-BSK805 is a potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor that potently suppressed recombinant human erythropoietin-induced polycythemia and extramedullary erythropoiesis in mice and rats.

NVP-BSK805

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Chemical Information

目录号 A11193
Mechanism of action Inhibitor
分子量 563.47
化学分子式 C27H28F2N6O.2HCl
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1092499-93-8
Synonyms NVPBSK805
SMILES code C1CNCCC1N2C=C(C=N2)C3=NC4=C(C=CC=C4N=C3)C5=CC(=C(C(=C5)F)CN6CCOCC6)F.Cl.Cl
化学名称 8-[3,5-Difluoro-4-(4-morpholinylmethyl)phenyl]-2-[1-(4-piperidinyl)-1H-pyrazol-4-yl]quinoxaline

生物活性

Description

NVP-BSK805 is a potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor that potently suppressed recombinant human erythropoietin-induced polycythemia and extramedullary erythropoiesis in mice and rats.

溶解性

Solubility (25°C) * In vitro DMSO 113 mg/mL (200.54 mM)
Water 3 mg/mL (5.32 mM)
Ethanol 15 mg/mL (26.62 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.75 mL 88.74 mL 177.47mL
0.5 mM 3.55 mL 17.75 mL 35.49 mL
1 mM 1.77 mL 8.87 mL 17.75 mL
5 mM 0.35 mL 1.77 mL 3.55 mL

*The above data is based on the productmolecular weight 563.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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