Obexelimab (XmAb5871) is a humanized monoclonal antibody targeting CD19, a protein expressed on the surface of B cells. This antibody functions by inhibiting the B cell receptor (BCR)-mediated calcium influx and enhancing the phosphorylation of Fc?? receptor IIb (Fc??RIIb). These actions collectively diminish B cell activation and functionality, ultimately inducing B cell apoptosis. Obexelimab is primarily utilized in research studies focusing on autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus, providing a valuable tool for investigating the pathophysiology and potential therapeutic interventions for these conditions.
Obexelimab (XmAb5871) is a humanized monoclonal antibody targeting CD19, a protein expressed on the surface of B cells. This antibody functions by inhibiting the B cell receptor (BCR)-mediated calcium influx and enhancing the phosphorylation of Fc?? receptor IIb (Fc??RIIb). These actions collectively diminish B cell activation and functionality, ultimately inducing B cell apoptosis. Obexelimab is primarily utilized in research studies focusing on autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus, providing a valuable tool for investigating the pathophysiology and potential therapeutic interventions for these conditions.
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