Ociperlimab is a humanized IgG1 monoclonal antibody targeting the T cell immunoreceptor with Ig and ITIM domains (TIGIT). It exhibits high-affinity binding to the extracellular domain of human TIGIT, with a dissociation constant (K_D) of 0.135 nM. By inhibiting the interaction between TIGIT and its ligands, poliovirus receptor (PVR) and PVR-like 2 (PVR-L2), Ociperlimab serves as a potent tool in the modulation of immune responses. This antibody is particularly useful in the research of cancer immunotherapy, facilitating the study of TIGIT as an immune checkpoint in various oncological models.
Ociperlimab is a humanized IgG1 monoclonal antibody targeting the T cell immunoreceptor with Ig and ITIM domains (TIGIT). It exhibits high-affinity binding to the extracellular domain of human TIGIT, with a dissociation constant (K_D) of 0.135 nM. By inhibiting the interaction between TIGIT and its ligands, poliovirus receptor (PVR) and PVR-like 2 (PVR-L2), Ociperlimab serves as a potent tool in the modulation of immune responses. This antibody is particularly useful in the research of cancer immunotherapy, facilitating the study of TIGIT as an immune checkpoint in various oncological models.
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