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OG-L002是一种有效的特异性LSD1抑制剂，IC50为20 nM，分别比MAO-B和MAO-A表现出36倍和69倍的选择性。
靶点信息
| LSD1 (Cell-free assay) | ||||
| 20 nM |
| In vitro (25°C) | DMSO | 41 mg/mL (181.99 mM) | |
| Water | Insoluble | ||
| Ethanol | 17 mg/mL (75.45 mM) | ||
| In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 19 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 38.2 mL | 191.02 mL | 382.04 mL |
| 0.5 mM | 7.64 mL | 38.2 mL | 76.41 mL |
| 1 mM | 3.82 mL | 19.1 mL | 38.2 mL |
| 5 mM | 0.76 mL | 3.82 mL | 7.64 mL |
*The above data is based on the productmolecular weight 261.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13246 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 261.75 |
| Formula | C15H15NO.HCl |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1357302-64-7 |
| Synonyms | OGL002, OG L002 |
| SMILES | CCOc1cc(ccc1Nc1ncc2c(n1)n(C)c1ccccc1c(=O)n2C)N1CCC(CC1)O |
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