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Oltipraz抑制HIF-1alpha活性和HIF-1alpha依赖性肿瘤生长，这可能是由于S6K1抑制结合H2O2清除作用导致HIF-1alpha稳定性降低所致。
靶点信息
| Nrf2 | ||||
| In vitro | DMSO | Warmed: 34 mg/mL (150.21 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 44.18 mL | 220.91 mL | 441.81 mL |
| 0.5 mM | 8.84 mL | 44.18 mL | 88.36 mL |
| 1 mM | 4.42 mL | 22.09 mL | 44.18 mL |
| 5 mM | 0.88 mL | 4.42 mL | 8.84 mL |
*The above data is based on the productmolecular weight 226.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13164 |
|---|---|
| 作用机制 | Activator (激活剂) |
| M. Wt | 226.34 |
| Formula | C8H6N2S3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 64224-21-1 |
| Synonyms | RP 35972, NSC 347901 |
| SMILES | CC1=C(SSC1=S)C2=NC=CN=C2 |
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