ON-01910 (rigosertib)

目录号: A10673

PLK 抑制剂

ON-01910 (rigosertib) Chemical Structure

CAS NO. 1225497-78-8

ON-01910 (rigosertib)通过涉及PI3K/AKT抑制和氧化应激诱导的双重作用机制对慢性淋巴细胞白血病细胞具有选择性的细胞毒性。

库存: 现货

规格 价格 数量
5 mg
¥ 600.00
10 mg
¥ 1,000.00
50 mg
¥ 2,800.00
100 mg
¥ 4,800.00
10mM * 1mL in DMSO
¥ 1,160.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

ON-01910 (rigosertib)通过涉及PI3K/AKT抑制和氧化应激诱导的双重作用机制对慢性淋巴细胞白血病细胞具有选择性的细胞毒性。
靶点信息
PLK1 (Cell-free assay)
9 nM
In vitro (25°C) DMSO 95 mg/mL (200.64 mM)
Water 95 mg/mL (200.64 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.12 mL 105.6 mL 211.19 mL
0.5 mM 4.22 mL 21.12 mL 42.24 mL
1 mM 2.11 mL 10.56 mL 21.12 mL
5 mM 0.42 mL 2.11 mL 4.22 mL

*The above data is based on the productmolecular weight 473.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10673
MECHANISM OF ACTION Inhibitor
M. Wt 473.5
Formula C21H24NNaO8S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1225497-78-8
Synonyms ON01910, ON 01910.Na, Estybon, Novonex, Rigosertib
SMILES COC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]

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