ON123300

Name: ON123300
SKU: A12584

目录号: A12584

CDK4 抑制剂?

ON123300 Chemical Structure

CAS NO. 1357470-29-1

ON123300是一种有效的多激酶抑制剂，对CDK4, Ark5, PDGFRβ, FGFR1, RET, Fyn的IC50分别为3.9 nM, 5 nM, 26 nM, 26 nM, 9.2 nM和11nM，可能对脑肿瘤化学治疗有用。ON123300强烈抑制Ark5和CDK4，以及生长因子受体酪氨酸激酶，如β-型血小板衍生的生长因子受体（PDGFRβ）。

库存：现货

规格	价格	数量
5 mg	￥ 1,200.00
10 mg	￥ 1,800.00
25 mg	￥ 4,000.00

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产品详情

溶解度 *

In vitro	DMSO	26 mg/mL (60.53 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.3 mL	116.49 mL	232.98 mL
0.5 mM	4.66 mL	23.3 mL	46.6 mL
1 mM	2.33 mL	11.65 mL	23.3 mL
5 mM	0.47 mL	2.33 mL	4.66 mL

*The above data is based on the productmolecular weight 429.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A12584
作用机制	Inhibitor (抑制剂)
M. Wt	429.23
Formula	C24H27N7O
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1357470-29-1
Synonyms	ON123300, ON 123300
SMILES	N#CC1=CC2=CN=C(NC3=CC=C(N4CCN(C)CC4)C=C3)N=C2N(C5CCCC5)C1=O