Onartuzumab (MetMAb) is a humanized, affinity-matured monovalent monoclonal antibody specifically targeting the MET receptor. This antibody effectively inhibits hepatocyte growth factor (HGF) binding, thereby preventing receptor phosphorylation and downstream signaling. Characterized by pharmacokinetics akin to those of typical antibodies, Onartuzumab demonstrates significant antitumor activity, making it a valuable tool for research in cancer biology and therapeutic development.
Onartuzumab (MetMAb) is a humanized, affinity-matured monovalent monoclonal antibody specifically targeting the MET receptor. This antibody effectively inhibits hepatocyte growth factor (HGF) binding, thereby preventing receptor phosphorylation and downstream signaling. Characterized by pharmacokinetics akin to those of typical antibodies, Onartuzumab demonstrates significant antitumor activity, making it a valuable tool for research in cancer biology and therapeutic development.
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