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ONX 0912 (Oprozomib)


proteasome inhibitor

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产品目录号: A14181


产品名 目录号 价格 数量
ONX 0912 5mg A14181-5
¥ 1,050.00
ONX 0912 10mg A14181-10
¥ 1,600.00
ONX 0912 25mg A14181-25
¥ 3,000.00
ONX 0912 10mM * 1mL in DMSO A14181-10mM-D
¥ 1,400.00



ONX 0912 is a tripeptide epoxyketone, which inhibits growth and induces apoptosis in MM cells resistant to conventional and bortezomib therapies.

ONX 0912 (Oprozomib)




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Chemical Information

目录号 A14181
Mechanism of action Inhibitor
分子量 532.2
化学分子式 C25H32N4O7S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 935888-69-0
Synonyms Oprozomib,ONX-0912,ONX0912
SMILES code CC1=NC=C(S1)C(=O)N[C@@H](COC)C(=O)N[C@@H](COC)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)[C@]3(CO3)C
化学名称 N-((S)-3-methoxy-1-(((S)-3-methoxy-1-(((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)-2-methylthiazole-5-carboxamide


ONX 0912 is a tripeptide epoxyketone, which inhibits growth and induces apoptosis in MM cells resistant to conventional and bortezomib therapies.
20S proteasome β5 20S proteasome LMP7
36 nM82 nM


Solubility (25°C)* In vitro DMSO 100 mg/mL (187.75 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.79 mL 93.95 mL 187.9mL
0.5 mM 3.76 mL 18.79 mL 37.58 mL
1 mM 1.88 mL 9.39 mL 18.79 mL
5 mM 0.38 mL 1.88 mL 3.76 mL

*The above data is based on the productmolecular weight 532.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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