ONX 0912 (Oprozomib)

目录号: A14181

Proteasome inhibitor

ONX 0912 (Oprozomib) Chemical Structure

CAS NO. 935888-69-0

ONX 0912 is a tripeptide epoxyketone, which inhibits growth and induces apoptosis in MM cells resistant to conventional and bortezomib therapies.

库存: 现货

规格 价格 数量
5 mg
¥ 1,050.00
10 mg
¥ 1,600.00
25 mg
¥ 3,000.00
10mM * 1mL in DMSO
¥ 1,400.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

ONX 0912 is a tripeptide epoxyketone, which inhibits growth and induces apoptosis in MM cells resistant to conventional and bortezomib therapies.
Targets
20S proteasome β5 20S proteasome LMP7
36 nM82 nM
In vitro DMSO 100 mg/mL (187.75 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.79 mL 93.95 mL 187.9 mL
0.5 mM 3.76 mL 18.79 mL 37.58 mL
1 mM 1.88 mL 9.39 mL 18.79 mL
5 mM 0.38 mL 1.88 mL 3.76 mL

*The above data is based on the productmolecular weight 532.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A14181
MECHANISM OF ACTION Inhibitor
M. Wt 532.2
Formula C25H32N4O7S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 935888-69-0
Synonyms Oprozomib,ONX-0912,ONX0912
SMILES CC1=NC=C(S1)C(=O)N[C@@H](COC)C(=O)N[C@@H](COC)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)[C@]3(CO3)C

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