ONX-0914

目录号: A12653

Immunoproteasome 抑制剂

ONX-0914

ONX-0914 Chemical Structure

CAS NO. 960374-59-8

ONX 0914是有效,选择性的免疫蛋白酶体亚基LMP7的抑制剂,在自身免疫性疾病(如类风湿性关节炎,炎性肠病和狼疮)中具有潜在的治疗应用。ONX 0914被设计为一种有效的免疫蛋白酶抑制剂,对组成型蛋白酶体的交叉反应最小。

库存: 现货

规格 价格 数量
5 mg
¥ 550.00
10 mg
¥ 800.00
25 mg
¥ 1,500.00
50 mg
¥ 2,450.00
10mM * 1mL in DMSO
¥ 850.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

ONX 0914是有效,选择性的免疫蛋白酶体亚基LMP7的抑制剂,在自身免疫性疾病(如类风湿性关节炎,炎性肠病和狼疮)中具有潜在的治疗应用。ONX 0914被设计为一种有效的免疫蛋白酶抑制剂,对组成型蛋白酶体的交叉反应最小。
靶点信息
LMP7 (Cell-free assay)
~10 nM
In vitro (25°C) DMSO 87 mg/mL (149.82 mM)
Water Insoluble
Ethanol 87 mg/mL (149.82 mM)
In vivo 2% DMSO+castor oil 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.22 mL 86.11 mL 172.21 mL
0.5 mM 3.44 mL 17.22 mL 34.44 mL
1 mM 1.72 mL 8.61 mL 17.22 mL
5 mM 0.34 mL 1.72 mL 3.44 mL

*The above data is based on the productmolecular weight 580.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A12653
作用机制 Inhibitor (抑制剂)
M. Wt 580.67
Formula C31H40N4O7
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 960374-59-8
Synonyms ONX0914, ONX 0914, PR-957
SMILES C[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)OC)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)[C@]3(CO3)C)NC(=O)CN4CCOCC4

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