Orilanolimab (SYNT001) is a humanized, de-immunized monoclonal antibody designed to block the neonatal Fc receptor (FcRn). By inhibiting the interaction between FcRn and the Fc portion of IgG molecules, Orilanolimab effectively impedes the activation of immune complexes (IC) mediated by FcRn. This action disrupts key pathways involved in IgG homeostasis, as well as innate and adaptive immune responses. This antibody is pivotal for research focused on the modulation of immune functions and the therapeutic regulation of antibody-mediated diseases.
Orilanolimab (SYNT001) is a humanized, de-immunized monoclonal antibody designed to block the neonatal Fc receptor (FcRn). By inhibiting the interaction between FcRn and the Fc portion of IgG molecules, Orilanolimab effectively impedes the activation of immune complexes (IC) mediated by FcRn. This action disrupts key pathways involved in IgG homeostasis, as well as innate and adaptive immune responses. This antibody is pivotal for research focused on the modulation of immune functions and the therapeutic regulation of antibody-mediated diseases.
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