Linsitinib (OSI-906)

Name: Linsitinib (OSI-906)
SKU: A11053
Price: 175 CNY
Rating: 5 (4 reviews)

目录号: A11053

IGF-1R 抑制剂

4 篇发表文献

OSI-906 是一种潜在的首创类选择性小分子，能够同时抑制胰岛素样生长因子-1受体（IGF-1R）和胰岛素受体（IR）的双重激酶抑制剂。

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Grouped product items
规格	价格	库存
2mg	¥175.00	现货
5mg	¥315.00	现货
10mg	¥455.00	现货
25mg	¥770.00	现货
50mg	¥1,120.00	现货
100mg	¥1,575.00	现货
*10mM 1mL in DMSO**	¥315.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用 Linsitinib (OSI-906)发表的4篇文献

Masao Kakoki, .et al. , Communications Biology, 2021, 4:775

Nakamura T, .et al. , J Med Food, 2018, Jul;21(7):701-708 PMID: 29583066

Tzeng SF, .et al. , FASEB J, 2018, Jun 15:fj201800687 PMID: 29906246

Takata N, .et al. , In Vitro Cell Dev Biol Anim., 2016, May;52(5):607-15 PMID: 26956358

生物活性

Discription

OSI-906 is a potential first-in-class selective small molecule, dual kinase inhibitor of both insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR).

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11053
分子式	C26H23N5O
分子量	421.5
CAS号	867160-71-2
SMILES	CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O
其他名称	OSI906, linsitinib
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	80 mg/mL (189.8 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5%DMSO+40%PEG300+5%Tween80+50%ddH2O	5.93 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.72 mL	118.62 mL	237.25 mL
0.5 mM	4.74 mL	23.72 mL	47.45 mL
1 mM	2.37 mL	11.86 mL	23.72 mL
5 mM	0.47 mL	2.37 mL	4.74 mL

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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