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OSI-930

促销

c-Kit/VEGFR 抑制剂

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产品目录号: A10679

库存状态:中国现货中国现货

产品名 目录号 价格 数量
OSI-930 5mg A10679-5
¥ 900.00
OSI-930 25mg A10679-25
¥ 2,000.00
OSI-930 50mg A10679-50
¥ 3,500.00
OSI-930 100mg A10679-100
¥ 6,000.00
OSI-930 10mM * 1mL in DMSO A10679-10mM-D
¥ 1,390.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

OSI-930 is a potent inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck with IC50 of 80 nM, 9 nM, 8 nM, 15 nM, 41 nM and 22 nM, respectively.

OSI-930

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Chemical Information

目录号 A10679
Mechanism of action Inhibitor
分子量 443.4
化学分子式 C22H16F3N3O2S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 728033-96-3
Synonyms OSI930
SMILES code C1=CC=C2C(=C1)C(=CC=N2)CNC3=C(SC=C3)C(=O)NC4=CC=C(C=C4)OC(F)(F)F
化学名称 3-[(4-Quinolinylmethyl)amino]-N-[4-(trifluoromethoxy)phenyl]-2-thiophenecarboxamide

生物活性

Description
OSI-930 is a potent inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck with IC50 of 80 nM, 9 nM, 8 nM, 15 nM, 41 nM and 22 nM, respectively.
Targets
Target Value
FLT1IC50: 8nM
KDRIC50: 9nM
CSF-1RIC50: 15nM
LCKIC50: 22nM
C-RafIC50: 41nM
KitIC50: 80nM
FLT3IC50: 1.303μM
PDGFRαIC50: 3.408μM
AblIC50: 4.738μM
PDGFRβIC50: 6.9μM
EGFRIC50: >10μM
AuroraAIC50: >10μM
AxlIC50: >10μM
CDK2/CyclinAIC50: >10μM
IKKβIC50: >10μM
MEK1IC50: >10μM
PDPK1IC50: >10μM
PKBβIC50: >10μM
Tie-2IC50: >10μM

溶解性

Solubility (25°C) * In vitro DMSO 89 mg/mL (200.7 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (6.76 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.55 mL 112.76 mL 225.53mL
0.5 mM 4.51 mL 22.55 mL 45.11 mL
1 mM 2.26 mL 11.28 mL 22.55 mL
5 mM 0.45 mL 2.26 mL 4.51 mL

*The above data is based on the productmolecular weight 443.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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