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OSU-03012 (AR-12)是一种有效的重组PDK-1(phosphoinositide-dependent kinase 1)抑制剂。
靶点信息
| PDK-1 (Cell-free assay) | ||||
| 5 μM |
| In vitro (25°C) | DMSO | 10 mg/mL (21.71 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 0.5% methylcellulose+0.2% Tween 80 | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.73 mL | 108.65 mL | 217.3 mL |
| 0.5 mM | 4.35 mL | 21.73 mL | 43.46 mL |
| 1 mM | 2.17 mL | 10.86 mL | 21.73 mL |
| 5 mM | 0.43 mL | 2.17 mL | 4.35 mL |
*The above data is based on the productmolecular weight 460.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10681 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 460.2 |
| Formula | C26H19F3N4O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 742112-33-0 |
| SMILES | C1=CC=C2C(=C1)C=CC3=C2C=CC(=C3)C4=CC(=NN4C5=CC=C(C=C5)NC(=O)CN)C(F)(F)F |
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