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OXF BD 02，BRD4第一个溴结构域的选择性抑制剂 (BRD4(1))( IC50 = 382 nM )。在CBP溴结构域上对BRD4(1)表现出2-3倍的选择性，并且对一系列其他溴结构域几乎没有亲和力。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 33.86 mL | 169.3 mL | 338.6 mL |
| 0.5 mM | 6.77 mL | 33.86 mL | 67.72 mL |
| 1 mM | 3.39 mL | 16.93 mL | 33.86 mL |
| 5 mM | 0.68 mL | 3.39 mL | 6.77 mL |
*The above data is based on the productmolecular weight 295.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16366 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 295.33 |
| Formula | C18H17NO3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1429129-68-9 |
| SMILES | OC1=CC(C2=C(C)ON=C2C)=CC(C(O)C3=CC=CC=C3)=C1 |
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