产品详情

生物活性

P 22077是泛素特异性蛋白酶(EC50 = 8.6 μM)和密切相关的双酶usp47。

Targets

Target	Value
USP7	EC50	8.6μM
USP47	EC50	8.74μM
USP2core	EC50	>50μM
USP4	EC50	>50μM
USP5	EC50	>50μM
USP8	EC50	>50μM
USP15	EC50	>50μM
USP20	EC50	>50μM
USP28	EC50	>50μM
JOSD2	EC50	>50μM
UCH-L1	EC50	>50μM
UCH-L3	EC50	>50μM
UCH-L5	EC50	>50μM
DEN1	EC50	>50μM
Plpro	EC50	>50μM
SENP6core	EC50	>50μM
PLA2	EC50	>50μM
Calpain1	EC50	>50μM
CT-L	EC50	>50μM
CathepsinD	EC50	>50μM
MMP13	EC50	>50μM
Trypsin	EC50	>50μM

溶解度 *

In vitro (25°C)	DMSO	57 mg/mL (180.76 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	2 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.71 mL	158.57 mL	317.14 mL
0.5 mM	6.34 mL	31.71 mL	63.43 mL
1 mM	3.17 mL	15.86 mL	31.71 mL
5 mM	0.63 mL	3.17 mL	6.34 mL

*The above data is based on the productmolecular weight 315.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A12933
作用机制	Inhibitor (抑制剂)
M. Wt	315.32
Formula	C12H7F2NO3S2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1247819-59-5
Synonyms	P22077
SMILES	CC(=O)C1=CC(=C(S1)SC2=C(C=C(C=C2)F)F)[N+](=O)[O-]