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CDK 抑制剂

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产品目录号: A13547


产品名 目录号 价格 数量
P276-00 5mg A13547-5
¥ 1,800.00
P276-00 10mg A13547-10
¥ 3,000.00
P276-00 25mg A13547-25
¥ 5,500.00
P276-00 10mM * 1mL in DMSO A13547-10mM-D
¥ 2,100.00



P276-00 is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. In Phase 2/3





顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A13547
Mechanism of action Inhibitor
分子量 438.3
化学分子式 C21H20ClNO5.HCl
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 920113-03-7
Synonyms P276, P276-00
SMILES code CN1CC[C@H]([C@@H]1CO)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl
化学名称 N/A


P276-00 is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. In Phase 2/3
Target Value
CDK9/CyclinT1IC50: 20nM
CDK4/CyclinD1IC50: 63nM
CDK1/CyclinBIC50: 79nM
CDK2/CyclinAIC50: 224nM
CDK6/CyclinD3IC50: 396nM
CDK2/CyclinEIC50: 2.54μM
GSK-3βIC50: 2.771μM
CDK7/CyclinHIC50: 2.87μM
c-SrcIC50: <10μM
PKCαIC50: 10μM
MAPK1IC50: 22μM
PKCIC50: 25μM
MAPK2IC50: >100μM
PKAIC50: 575μM


Solubility (25°C) * In vitro DMSO 88 mg/mL (200.77 mM)
Water 88 mg/mL (200.77 mM)
Ethanol 7 mg/mL (15.97 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.82 mL 114.08 mL 228.15mL
0.5 mM 4.56 mL 22.82 mL 45.63 mL
1 mM 2.28 mL 11.41 mL 22.82 mL
5 mM 0.46 mL 2.28 mL 4.56 mL

*The above data is based on the productmolecular weight 438.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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