P276-00

目录号: A13547

CDK Inhibitor

P276-00

P276-00 Chemical Structure

CAS NO. 920113-03-7

P276-00 is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. In Phase 2/3

库存: 现货

规格 价格 数量
5 mg
¥ 1,800.00
10 mg
¥ 3,000.00
25 mg
¥ 5,500.00
10mM * 1mL in DMSO
¥ 2,100.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

P276-00 is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. In Phase 2/3
Targets
Target Value
CDK9/CyclinT1IC50: 20nM
CDK4/CyclinD1IC50: 63nM
CDK1/CyclinBIC50: 79nM
CDK2/CyclinAIC50: 224nM
CDK6/CyclinD3IC50: 396nM
CDK2/CyclinEIC50: 2.54μM
GSK-3βIC50: 2.771μM
CDK7/CyclinHIC50: 2.87μM
c-SrcIC50: <10μM
PKCαIC50: 10μM
MAPK1IC50: 22μM
PKCIC50: 25μM
MAPK2IC50: >100μM
PKAIC50: 575μM
In vitro (25°C) DMSO 88 mg/mL (200.77 mM)
Water 88 mg/mL (200.77 mM)
Ethanol 7 mg/mL (15.97 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.82 mL 114.08 mL 228.15 mL
0.5 mM 4.56 mL 22.82 mL 45.63 mL
1 mM 2.28 mL 11.41 mL 22.82 mL
5 mM 0.46 mL 2.28 mL 4.56 mL

*The above data is based on the productmolecular weight 438.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A13547
MECHANISM OF ACTION Inhibitor
M. Wt 438.3
Formula C21H20ClNO5.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 920113-03-7
Synonyms P276, P276-00
SMILES CN1CC[C@H]([C@@H]1CO)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl

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