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P505-15 (PRT062607, BIIB057)

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Syk 抑制剂

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产品目录号: A11952

库存状态:中国现货中国现货

产品名 目录号 价格 数量
P505-15 5mg A11952-5
¥ 1,000.00
P505-15 10mg A11952-10
¥ 1,800.00
P505-15 25mg A11952-25
¥ 3,500.00
P505-15 50mg A11952-50
¥ 6,000.00
P505-15 10mM * 1mL in DMSO A11952-10mM-D
¥ 1,380.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

P505-15 (also known as PRT062607) is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases.

P505-15 (PRT062607, BIIB057)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 P505-15 (PRT062607, BIIB057) 发表的文献 (1)
  • Li T, .et al. Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma, Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190

Chemical Information

目录号 A11952
Mechanism of action Inhibitor
分子量 393.45
化学分子式 C19H23N9O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1370261-96-3
Synonyms P50515, PRT062607
SMILES code CC(=O)O.C1CC[C@H]([C@H](C1)N)NC2=NC=C(C(=N2)NC3=CC=CC(=C3)N4N=CC=N4)C(=O)N
化学名称 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-((1R,2S)-2-aminocyclohexylamino) pyrimidine-5-carboxamide

生物活性

Description
P505-15 (also known as PRT062607) is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases.

溶解性

Solubility (25°C) * In vitro DMSO 86 mg/mL (200.04 mM)
Water 86 mg/mL (200.04 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.42 mL 127.08 mL 254.16mL
0.5 mM 5.08 mL 25.42 mL 50.83 mL
1 mM 2.54 mL 12.71 mL 25.42 mL
5 mM 0.51 mL 2.54 mL 5.08 mL

*The above data is based on the productmolecular weight 393.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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