P505-15 (PRT062607, BIIB057)

Name: P505-15 (PRT062607, BIIB057)
SKU: A11952
Price: 665 CNY
Rating: 5 (1 reviews)

目录号: A11952

Syk 抑制剂

1 篇发表文献

P505-15（又名PRT062607）是一种新型、高度选择性、口服生物利用度的小分子SYK抑制剂（SYK IC(50) = 1 nM），其抗SYK活性至少比对其他激酶的亲和力高出80倍。

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Grouped product items
规格	价格	库存
5mg	¥665.00	现货
10mg	¥1,225.00	现货
25mg	¥2,415.00	现货
50mg	¥4,165.00	现货
*10mM 1mL in DMSO**	¥966.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用P505-15 (PRT062607, BIIB057)发表的1篇文献

Li T, .et al. , Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190

生物活性

Discription

P505-15 (also known as PRT062607) is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases.

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11952
分子式	C19H23N9O
分子量	393.45
CAS号	1370261-96-3
SMILES	C1CC[C@H]([C@H](C1)N)NC2=NC=C(C(=N2)NC3=CC(=CC=C3)N4N=CC=N4)C(=O)N
其他名称	P50515, PRT062607
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	85 mg/mL (197.71 mM)
	Water	85 mg/mL (197.71 mM)
	Ethanol	Insoluble
In vivo	Saline	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.42 mL	127.08 mL	254.16 mL
0.5 mM	5.08 mL	25.42 mL	50.83 mL
1 mM	2.54 mL	12.71 mL	25.42 mL
5 mM	0.51 mL	2.54 mL	5.08 mL

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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