PA-824 (Pretomanid)

Name: PA-824 (Pretomanid)
SKU: A11401
Price: 245 CNY
Rating: 5 (5 reviews)

目录号: A11401

5 篇发表文献

PA-824 是一种实验性的抗结核药物。

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Grouped product items
规格	价格	库存
5mg	¥245.00	现货
10mg	¥420.00	现货
25mg	¥630.00	现货
50mg	¥805.00	现货
100mg	¥1,295.00	现货
*10mM 1mL in DMSO**	¥280.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用PA-824 (Pretomanid)发表的5篇文献

Pablo Rodriguez-Fernandez, .et al. , ACS Infect Dis, 2024, Jan 12;10(1):170-183 PMID: 38085851

Vijaya Bharti, .et al. , Cell Rep, 2022, Dec 20;41(12):111826 PMID: 36543138

Thanh Quang Nguyen, .et al. , Antimicrob Agents Chemother, 2022, Dec 20;66(12):e0044822 PMID: 36321819

Wang X, .et al. , Cell Chem Biol, 2019, Nov 7. pii: S2451-9456(19)30355-1 PMID: 31711854

Alexandre López-Gavín, .et al. , Int J Antimicrob Agents., 2015, Nov;46(5):582-5 PMID: 26421981

生物活性

Discription

PA-824 is an experimental anti-tuberculosis drug.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

In Vitro

PA-824 (Pretomanid) is a promising nitroimidazole drug with potent activity against Mycobacterium tuberculosis. In vitro, PA-824 demonstrates high efficacy against both drug-sensitive and multidrug-resistant (MDR) strains of M. tuberculosis, with MIC values typically below 1 μg/ml. Its activity spans clinical isolates from diverse geographic regions, including Asia (India and South Korea) and the United States, with MICs ranging between 0.015 and 0.25 μg/ml. [1]

A study investigating resistance mechanisms revealed that mutations in PA-824 resistance-associated genes, such as fgd1 (Rv0407) and ddn (Rv3547), do not significantly impact its MICs, suggesting its robustness against certain resistance mutations (MICs ≤ 0.25 μg/ml). [2]

Moreover, PA-824 has been shown to exert bactericidal activity under hypoxic conditions, targeting both replicating and non-replicating M. tuberculosis populations. This unique dual-phase activity further emphasizes its potential in treating both active and latent tuberculosis infections. [3]

References

Clark RW, et al. Arterioscler Thromb Vasc Biol. 2004;24(3):490-497. PMID: 14726526
Hu X, et al. Endocrinology. 2009;150(5):2211-2219. PMID: 19179443
Barter PJ, et al. N Engl J Med. 2007;357(21):2109-2122. PMID: 17984165

产品信息

目录号	A11401
分子式	C14H12F3N3O5
分子量	359.3
CAS号	187235-37-6
SMILES	C1[C@@H](COC2=NC(=CN21)[N+](=O)[O-])OCC3=CC=C(C=C3)OC(F)(F)F
其他名称	PA824
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	64 mg/mL (178.14 mM)
	Water	Insoluble
	Ethanol	14 mg/mL (38.96 mM)
In vivo	0.5% methylcellulose	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.83 mL	139.16 mL	278.32 mL
0.5 mM	5.57 mL	27.83 mL	55.66 mL
1 mM	2.78 mL	13.92 mL	27.83 mL
5 mM	0.56 mL	2.78 mL	5.57 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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