Pacritinib (SB1518)

目录号: A12694

JAK2/FLT3 抑制剂

Pacritinib (SB1518) Chemical Structure

CAS NO. 937272-79-2

Pacritinib, also known as SB1518, is an orally bioavailable inhibitor of Janus kinase 2 (JAK2) and the JAK2 mutant JAK2V617F with potential antineoplastic activity. Pacritinib competes with JAK2 for ATP binding, which may result in inhibition of JAK2 activation, inhibition of the JAK-STAT signaling pathway, and so caspase-dependent apoptosis.

库存: 现货

规格 价格 数量
5 mg
¥ 700.00
10 mg
¥ 1,000.00
25 mg
¥ 1,800.00
50 mg
¥ 2,600.00
10mM * 1mL in DMSO
¥ 2,480.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

Pacritinib, also known as SB1518, is an orally bioavailable inhibitor of Janus kinase 2 (JAK2) and the JAK2 mutant JAK2V617F with potential antineoplastic activity. Pacritinib competes with JAK2 for ATP binding, which may result in inhibition of JAK2 activation, inhibition of the JAK-STAT signaling pathway, and so caspase-dependent apoptosis.
In vitro DMSO 11 mg/mL heating (23.27 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.16 mL 105.8 mL 211.6 mL
0.5 mM 4.23 mL 21.16 mL 42.32 mL
1 mM 2.12 mL 10.58 mL 21.16 mL
5 mM 0.42 mL 2.12 mL 4.23 mL

*The above data is based on the productmolecular weight 472.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A12694
MECHANISM OF ACTION Inhibitor
M. Wt 472.58
Formula C28H32N4O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 937272-79-2
Synonyms SB-1518; SB 1518
SMILES C1CCN(C1)CCOC2=C3COC/C=C/COCC4=CC=CC(=C4)C5=NC(=NC=C5)NC(=C3)C=C2

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