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Palbociclib

CDK 抑制剂

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产品目录号: A14427

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Palbociclib 10mg A14427-10
¥ 700.00
Palbociclib 25mg A14427-25
¥ 800.00
Palbociclib 50mg A14427-50
¥ 900.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Palbociclib is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.

Palbociclib

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Palbociclib 发表的文献 (2)
  • Hidemasa Matsuo, .et al. Recurrent CCND3 mutations in MLL-rearranged acute myeloid leukemia, Blood Adv, 2018, Nov 13; 2(21): 2879每2889 PMID: 30381403
  • Zhihong Li, .et al. Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3., J Med Chem., 2014, Apr 24;57(8):3430-49. PMID: 24641103

Chemical Information

目录号 A14427
Mechanism of action Inhibitor
分子量 447.53
化学分子式 C24H29N7O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 571190-30-2
Synonyms PD0332991, PD-0332991, PD 0332991
SMILES code CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C
化学名称 6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one

生物活性

Description
Palbociclib is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.34 mL 111.72 mL 223.45mL
0.5 mM 4.47 mL 22.34 mL 44.69 mL
1 mM 2.23 mL 11.17 mL 22.34 mL
5 mM 0.45 mL 2.23 mL 4.47 mL

*The above data is based on the productmolecular weight 447.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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