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Paprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 40.77 mL | 203.85 mL | 407.7 mL |
| 0.5 mM | 8.15 mL | 40.77 mL | 81.54 mL |
| 1 mM | 4.08 mL | 20.38 mL | 40.77 mL |
| 5 mM | 0.82 mL | 4.08 mL | 8.15 mL |
*The above data is based on the productmolecular weight 245.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A20346 |
|---|---|
| M. Wt | 245.28 |
| Formula | C16H11N3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 57046-73-8 |
| SMILES | N#C/C(C1=CNC2=CC=CC=C21)=C\C3=CN=CC=C3 |
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