Pavurutamab (AMG-701) is a bispecific T-cell engager that targets both CD3 on T-cells and B-cell maturation antigens (BCMA) on plasma cells. This molecule is engineered with an extended half-life derivative of Pacanalotamab, enhancing its stability and duration of action. The Fc region of Pavurutamab has been modified to incorporate molecules that optimize its pharmacokinetic properties, ensuring sustained efficacy. This biologic is primarily investigated for its potential therapeutic applications in the modulation of immune responses and as a treatment for multiple myeloma (MM).
Pavurutamab (AMG-701) is a bispecific T-cell engager that targets both CD3 on T-cells and B-cell maturation antigens (BCMA) on plasma cells. This molecule is engineered with an extended half-life derivative of Pacanalotamab, enhancing its stability and duration of action. The Fc region of Pavurutamab has been modified to incorporate molecules that optimize its pharmacokinetic properties, ensuring sustained efficacy. This biologic is primarily investigated for its potential therapeutic applications in the modulation of immune responses and as a treatment for multiple myeloma (MM).
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