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Pazopanib (GW-786034)

促销

VEGFR 抑制剂

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产品目录号: A11518

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Pazopanib 25mg A11518-25
¥ 650.00
Pazopanib 50mg A11518-50
¥ 1,200.00
Pazopanib 100mg A11518-100
¥ 2,000.00
Pazopanib(GW-786034) 10mM * 1mL in DMSO A11518-10mM-D
¥ 700.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis.

Pazopanib (GW-786034)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Pazopanib (GW-786034) 发表的文献 (3)
  • Koide H, .et al. Substrate-dependent effects of molecular-targeted anticancer agents on activity of organic anion transporting polypeptide 1B1, Xenobiotica, 2018, Oct;48(10):1059-1071 PMID: 29034773
  • Ellawatty WEA, .et al. Organic cation transporter 1 is responsible for hepatocellular uptake of the tyrosine kinase inhibitor pazopanib, Drug Metab Dispos, 2018, Jan;46(1):33-40 PMID: 29089306
  • Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358

Chemical Information

目录号 A11518
Mechanism of action Inhibitor
分子量 437.5
化学分子式 C21H23N7O2S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 444731-52-6
Synonyms GW 786034, Votrient,GW786034
SMILES code CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
化学名称 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzolsulfonamide

生物活性

Description
Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis.
Targets
Target Value
VEGFR1IC50: 10nM
VEGFR2IC50: 30nM
VEGFR3IC50: 47nM
FGFRIC50: 74nM
PDGFRIC50: 84nM
c-KitIC50: 140nM
c-FmsIC50: 146nM

溶解性

Solubility (25°C)* In vitro DMSO 88 mg/mL (201.13 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.86 mL 114.29 mL 228.57mL
0.5 mM 4.57 mL 22.86 mL 45.71 mL
1 mM 2.29 mL 11.43 mL 22.86 mL
5 mM 0.46 mL 2.29 mL 4.57 mL

*The above data is based on the productmolecular weight 437.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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