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PCI-24781 (Abexinostat)

促销

HDAC 抑制剂

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产品目录号: A10700

库存状态:中国现货中国现货 Shipped in 7-10 Days

产品名 目录号 价格 数量
PCI-24781 5mg A10700-5
¥ 800.00
PCI-24781 10mg A10700-10
¥ 1,400.00
PCI-24781 50mg A10700-50
¥ 4,000.00
PCI-24781 100mg A10700-100
¥ 7,000.00
PCI-24781 10mM * 1mL in DMSO A10700-10mM-D
¥ 1,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

PCI-24781 is a broad-spectrum phenyl hydroxamic acid HDAC inhibitor.

PCI-24781 (Abexinostat)

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Chemical Information

目录号 A10700
Mechanism of action Inhibitor
分子量 397.4
化学分子式 C21H23N3O5
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 783355-60-2
Synonyms PCI24781, CRA-024781
SMILES code CN(C)CC1=C(OC2=CC=CC=C21)C(=O)NCCOC3=CC=C(C=C3)C(=O)NO
化学名称 3-[(Dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-2-benzofurancarboxamide

生物活性

Description
PCI-24781 is a broad-spectrum phenyl hydroxamic acid HDAC inhibitor.
Targets
Target Value
HDAC1ki: 7nM
HDAC3/SMRTki: 8.2nM
HDAC6ki: 17nM
HDAC2ki: 19nM
HDAC10IC50: 24nM
HDAC8IC50: 280nM

溶解性

Solubility (25°C)* In vitro DMSO 80 mg/mL (201.29 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.16 mL 125.82 mL 251.64mL
0.5 mM 5.03 mL 25.16 mL 50.33 mL
1 mM 2.52 mL 12.58 mL 25.16 mL
5 mM 0.5 mL 2.52 mL 5.03 mL

*The above data is based on the productmolecular weight 397.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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