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PCI-24781 (Abexinostat)

PCI-24781 (Abexinostat)

Name: PCI-24781 (Abexinostat)
SKU: A10700

目录号: A10700

HDAC 抑制剂

PCI-24781 (Abexinostat) Chemical Structure

CAS NO. 783355-60-2

PCI-24781 (Abexinostat)是一种广谱苯基异羟肟酸HDAC抑制剂。

库存：现货 Shipped in 7-10 Days

规格	价格	数量
5 mg	￥ 800.00
10 mg	￥ 1,200.00
50 mg	￥ 3,800.00
100 mg	￥ 6,000.00
10mM * 1mL in DMSO	￥ 1,000.00

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生物活性

PCI-24781 (Abexinostat)是一种广谱苯基异羟肟酸HDAC抑制剂。

Targets

Target	Value
HDAC1	ki: 7nM
HDAC3/SMRT	ki: 8.2nM
HDAC6	ki: 17nM
HDAC2	ki: 19nM
HDAC10	IC50: 24nM
HDAC8	IC50: 280nM

溶解度 *

In vitro	DMSO	72 mg/mL (181.16 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.16 mL	125.82 mL	251.64 mL
0.5 mM	5.03 mL	25.16 mL	50.33 mL
1 mM	2.52 mL	12.58 mL	25.16 mL
5 mM	0.5 mL	2.52 mL	5.03 mL

*The above data is based on the productmolecular weight 397.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10700
作用机制	Inhibitor (抑制剂)
M. Wt	397.4
Formula	C21H23N3O5
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	783355-60-2
Synonyms	PCI24781, CRA-024781
SMILES	CN(C)CC1=C(OC2=CC=CC=C21)C(=O)NCCOC3=CC=C(C=C3)C(=O)NO