Trusted by 10,000+ Scientists since 2006
微信关注
申请试用装

PCI-32765 (Ibrutinib)

促销

Bruton tyrosine kinase 抑制剂

0 Customer Reviews
产品目录号: A11020

库存状态:中国现货中国现货

产品名 目录号 价格 数量
PCI-32765 5mg A11020-5
¥ 500.00
PCI-32765 10mg A11020-10
¥ 650.00
PCI-32765 25mg A11020-25
¥ 1,000.00
PCI-32765 100mg A11020-100
¥ 1,500.00
PCI-32765 10mM * 1mL in DMSO A11020-10mM-D
¥ 500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

PCI-32765 is an orally bioavailable small-molecule inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.

PCI-32765 (Ibrutinib)

双击上述图片即可查看完整大小

缩小
放大

更多视图

顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 PCI-32765 (Ibrutinib) 发表的文献 (3)
  • Carolin N. Zorn, .et al. Stimulus strength determines the BTK-dependence of the SHIP1-deficient phenotype in IgE/antigen-triggered mast cells, Sci Rep, 2018, 8: 15467 PMID: 30341350
  • Li T, .et al. Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma, Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190
  • Brittany M. Duggan, .et al. Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia, Sci Rep, 2017, 7: 1578 PMID: 28484277

Chemical Information

目录号 A11020
Mechanism of action Inhibitor
分子量 440.5
化学分子式 C25H24N6O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 936563-96-1
Synonyms Ibrutinib
SMILES code C=CC(=O)N1CCC[C@H](C1)N2C3=C(C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=NC=N3)N
化学名称 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one

生物活性

Description
PCI-32765 is an orally bioavailable small-molecule inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.
Targets
Target Value
BTKIC50: 0.5nM
BLKIC50: 0.5nM
BmxIC50: 0.8nM
CSKIC50: 2.3nM
FGRIC50: 2.3nM
BRKIC50: 3.3nM
HckIC50: 3.7nM
EGFRIC50: 5.6nM
YESIC50: 6.5nM
ErbB2IC50: 9.4nM
ITKIC50: 10.7nM
JAK3IC50: 16.1nM
FRKIC50: 29.2nM
LCKIC50: 33.2nM
RETIC50: 36.5nM
FLT3IC50: 73nM
TECIC50: 78nM
AblIC50: 86nM
FynIC50: 96nM
RIPK2IC50: 152nM
c-SrcIC50: 171nM
LynIC50: 200nM
PDGFRαIC50: 718nM
FmsIC50: 5.545μM
FERIC50: 8.07μM
JAK1IC50: >10μM
JAK2IC50: >10μM
NEK2IC50: >10μM
p38IC50: >10μM
PI3KIC50: >10μM
PLK1IC50: >10μM
RSK1IC50: >10μM
SykIC50: >10μM

溶解性

Solubility (25°C) * In vitro DMSO 88 mg/mL (199.77 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 12 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.7 mL 113.51 mL 227.01mL
0.5 mM 4.54 mL 22.7 mL 45.4 mL
1 mM 2.27 mL 11.35 mL 22.7 mL
5 mM 0.45 mL 2.27 mL 4.54 mL

*The above data is based on the productmolecular weight 440.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Reference:

 

[1]. Pan, Z; Scheerens, H; Li, SJ; Schultz, BE; Sprengeler, PA; Burrill, LC; Mendonca, RV; Sweeney, MD; Scott, KC; Grothaus, Paul G.; Jeffery, Douglas A.; Spoerke, Jill M.; Honigberg, Lee A.; Young, Peter R.; Dalrymple, Stacie A.; Palmer, James T. (2007). “Discovery of selective irreversible inhibitors for Bruton’s tyrosine kinase”. ChemMedChem 2 (1): 58–61.

[2]. Honigberg, LA; Smith, AM; Sirisawad, M; Verner, E; Loury, D; Chang, B; Li, S; Pan, Z; Thamm, DH; Miller, RA; Buggy, JJ (2010). “The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy”. Proceedings of the National Academy of Sciences of the United States of America 107 (29): 13075–80.

[3]. Ponader S, Chen SS, Buggy JJ, Balakrishnan K, Gandhi V, Wierda WG, Keating MJ, O’Brien S, Chiorazzi N, Burger JA (2012). The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo 119. Blood. pp. 1182–1189.

 

Read More

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

产品标签

使用空格分隔标签。使用单引号(')标注词组。


Keywords:购买 PCI-32765 (Ibrutinib) | PCI-32765 (Ibrutinib) 供应商 | 订购 PCI-32765 (Ibrutinib) | PCI-32765 (Ibrutinib) 价格 | PCI-32765 (Ibrutinib) 生产商 | 订单 PCI-32765 (Ibrutinib) | PCI-32765 (Ibrutinib) 代理商 | 购买 936563-96-1| 936563-96-1 供应商 | 订购 936563-96-1 | 936563-96-1 价格 | 936563-96-1 生产商 | 订单 936563-96-1 | 936563-96-1 代理商|buy PCI-32765 (Ibrutinib) | PCI-32765 (Ibrutinib) Supplier | purchase PCI-32765 (Ibrutinib) | PCI-32765 (Ibrutinib) cost | PCI-32765 (Ibrutinib) manufacturer | order PCI-32765 (Ibrutinib) | PCI-32765 (Ibrutinib) distributor | buy 936563-96-1| 936563-96-1 Supplier | purchase 936563-96-1 | 936563-96-1 cost | 936563-96-1 manufacturer | order 936563-96-1 | 936563-96-1 distributor