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PCI-34051

促销

HDAC 抑制剂

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产品目录号: A11152

库存状态:中国现货中国现货

产品名 目录号 价格 数量
PCI-34051 10mg A11152-10
¥ 1,000.00
PCI-34051 25mg A11152-25
¥ 2,000.00
PCI-34051 50mg A11152-50
¥ 3,500.00
PCI-34051 100mg A11152-100
¥ 6,600.00
PCI-34051 10mM * 1mL in DMSO A11152-10mM-D
¥ 600.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

PCI-34051 is a specific and potent histone deacetylase 8 (HDAC8) inhibitor, with >200-fold selectivity over the other HDAC isoforms.

PCI-34051

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Chemical Information

目录号 A11152
Mechanism of action Inhibitor
分子量 296.3
化学分子式 C17H16N2O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 950762-95-5
Synonyms PCI34051
SMILES code COC1=CC=C(C=C1)CN2C=CC3=C2C=C(C=C3)C(=O)NO
化学名称 N-Hydroxy-1-(4-methoxybenzyl)-1H-indole-6-carboxamide

生物活性

Description
PCI-34051 is a specific and potent histone deacetylase 8 (HDAC8) inhibitor, with >200-fold selectivity over the other HDAC isoforms.
Targets
Target Value
HDAC8IC50: 10nM
HDAC6IC50: 2.9μM
HDAC1IC50: 4μM
HDAC10IC50: 13μM
HDAC2IC50: >50μM
HDAC3IC50: >50μM

溶解性

Solubility (25°C) * In vitro DMSO 59 mg/mL (199.1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 33.75 mL 168.75 mL 337.5mL
0.5 mM 6.75 mL 33.75 mL 67.5 mL
1 mM 3.37 mL 16.87 mL 33.75 mL
5 mM 0.67 mL 3.37 mL 6.75 mL

*The above data is based on the productmolecular weight 296.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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