产品详情

生物活性

PCI-34051是一种有效的特异性组蛋白脱乙酰基酶8（HDAC8）抑制剂，其选择性是其他HDAC亚型的200倍以上。

Targets

Target	Value
HDAC8	IC50: 10nM
HDAC6	IC50: 2.9μM
HDAC1	IC50: 4μM
HDAC10	IC50: 13μM
HDAC2	IC50: >50μM
HDAC3	IC50: >50μM

溶解度 *

In vitro (25°C)	DMSO	58 mg/mL (195.73 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+40%PEG300+5% tween80+50% H2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	33.75 mL	168.75 mL	337.5 mL
0.5 mM	6.75 mL	33.75 mL	67.5 mL
1 mM	3.37 mL	16.87 mL	33.75 mL
5 mM	0.67 mL	3.37 mL	6.75 mL

*The above data is based on the productmolecular weight 296.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11152
作用机制	Inhibitor (抑制剂)
M. Wt	296.3
Formula	C17H16N2O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	950762-95-5
Synonyms	PCI34051
SMILES	COC1=CC=C(C=C1)CN2C=CC3=C2C=C(C=C3)C(=O)NO