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PD 0332991 HCl (Palbociclib)

促销

CDK 4/6 抑制剂

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产品目录号: A10701

库存状态:中国现货中国现货

产品名 目录号 价格 数量
PD 0332991 HCl 5mg A10701-5
¥ 500.00
PD 0332991 HCl 10mg A10701-10
¥ 700.00
PD 0332991 HCl 25mg A10701-25
¥ 850.00
PD 0332991 HCl 50mg A10701-50
¥ 1,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.

PD 0332991 HCl (Palbociclib)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 PD 0332991 HCl (Palbociclib) 发表的文献 (2)
  • Cong Li, .et al. AMG 925 is a dual FLT3/CDK4 inhibitor with the potential to overcome FLT3 inhibitor resistance in acute myeloid leukemia., Mol Cancer Ther., 2015, Feb;14(2):375-83. PMID: 25487917
  • Pirita Pekkonen, .et al. KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo, Cell Cycle., 2014, Dec 1; 13(23): 3670每3684. PMID: 25483078

Chemical Information

目录号 A10701
Mechanism of action Inhibitor
分子量 447.5
化学分子式 C24H29N7O2.HCl
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 827022-32-2
Synonyms N/A
SMILES code CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C.Cl
化学名称 Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-, monohydrochloride

生物活性

Description
PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.
Targets
Target Value
CDK4/CyclinD3IC50: 9nM
CDK4/CyclinD1IC50: 11nM
CDK6/CyclinD2IC50: 15nM
CDK2/CyclinE2IC50: >10μM
CDK2/CyclinAIC50: >10μM
CDK1/CyclinBIC50: >10μM
CDK5/p25IC50: >10μM
EGFRIC50: >10μM
FGFRIC50: >10μM
PDGFRIC50: >10μM
Insulin ReceptorIC50: >10μM
VEGFRIC50: >10μM
AMPKIC50: >10μM
Chk1IC50: >10μM
CK1IC50: >10μM
CK2IC50: >10μM
c-SrcIC50: >10μM
GSK-3βIC50: >10μM
MAPK2/ERK2IC50: >10μM
MAPKAPK2IC50: >10μM
PKBIC50: >10μM
PKCIC50: >10μM
PHKIC50: >10μM
SAPK2aIC50: >10μM
SAPK3IC50: >10μM
SAPK4IC50: >10μM

溶解性

Solubility (25°C) * In vitro DMSO 3 mg/mL (6.19 mM)
Water 30 mg/mL (61.98 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.35 mL 111.73 mL 223.46mL
0.5 mM 4.47 mL 22.35 mL 44.69 mL
1 mM 2.23 mL 11.17 mL 22.35 mL
5 mM 0.45 mL 2.23 mL 4.47 mL

*The above data is based on the productmolecular weight 447.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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