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PD173074

促销

FGFR1/VEGFR2 抑制剂

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产品目录号: A10703

库存状态:中国现货中国现货

产品名 目录号 价格 数量
PD173074 5mg A10703-5
¥ 300.00
PD173074 10mg A10703-10
¥ 500.00
PD173074 50mg A10703-50
¥ 1,400.00
PD173074 100mg A10703-100
¥ 2,200.00
PD173074 10mM * 1mL in DMSO A10703-10mM-D
¥ 500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

PD173074 is a potent, cell permeable and ATP competitive inhibitor of FGFR and VEGFR.

PD173074

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 PD173074 发表的文献 (1)
  • Cheryl Q.E. Lee, .et al. What Is Trophoblast? A Combination of Criteria Define Human First-Trimester Trophoblast, Stem Cell Reports, 2016, Feb 9; 6(2): 257每272 PMID: 26862703

Chemical Information

目录号 A10703
Mechanism of action Inhibitor
分子量 523.7
化学分子式 C28H41N7O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 219580-11-7
Synonyms PD-173074
SMILES code CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C
化学名称 N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea

生物活性

Description
PD173074 is a potent, cell permeable and ATP competitive inhibitor of FGFR and VEGFR.
Targets
Target Value
FGFR1IC50: ~25nM
VEGFR2IC50: 100nM-200nM
c-SrcIC50: 19.8μM
EGFRIC50: >50μM
Insulin ReceptorIC50: >50μM
MEKIC50: >50μM
PKCIC50: >50μM

溶解性

Solubility (25°C)* In vitro DMSO 100 mg/mL (190.95 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (190.95 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.09 mL 95.47 mL 190.95mL
0.5 mM 3.82 mL 19.09 mL 38.19 mL
1 mM 1.91 mL 9.55 mL 19.09 mL
5 mM 0.38 mL 1.91 mL 3.82 mL

*The above data is based on the productmolecular weight 523.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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