PD184352 (CI-1040)

Name: PD184352 (CI-1040)
SKU: A10212
Price: 245 CNY
Rating: 5 (2 reviews)

目录号: A10212

MEK1/2 抑制剂

2 篇发表文献

PD184352（CI-1040）是一种ATP非竞争性的MEK1/2抑制剂，在细胞测试中的IC50为17 nM，对MEK1/2的选择性比MEK5高出100倍。目前处于临床试验第二阶段。

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Grouped product items
规格	价格	库存
5mg	¥245.00	现货
10mg	¥455.00	现货
25mg	¥1,015.00	现货
50mg	¥1,575.00	现货
100mg	¥2,660.00	现货
200mg	¥3,325.00	现货
*10mM 1mL in DMSO**	¥315.00	现货
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Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用PD184352 (CI-1040) 发表的2篇文献

Sachio Suzuki, .et al. , Cell Chem Biol, 2022, Sep 15;29(9):1446-1464 PMID: 35835118

Masaru Yoshikawa, .et al. , J Am Chem Soc, 2021, May 5;143(17):6434-6446 PMID: 33890764

生物活性

Discription

PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10212
分子式	C17H14ClF2IN2O2
分子量	478.7
CAS号	212631-79-3
SMILES	C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	92 mg/mL (192.19 mM)
	Water	Insoluble
	Ethanol	13 mg/mL (27.15 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol, pH 9	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.89 mL	104.45 mL	208.9 mL
0.5 mM	4.18 mL	20.89 mL	41.78 mL
1 mM	2.09 mL	10.44 mL	20.89 mL
5 mM	0.42 mL	2.09 mL	4.18 mL

Useful Calculator

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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