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PD184352 (CI-1040)


MEK1/2 抑制剂

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产品目录号: A10212


产品名 目录号 价格 数量
PD184352 5mg A10212-5
¥ 400.00
PD184352 10mg A10212-10
¥ 750.00
PD184352 25mg A10212-25
¥ 1,500.00
PD184352 100mg A10212-100
¥ 4,200.00
PD184352 (CI-1040) 10mM * 1mL in DMSO A10212-10mM-D
¥ 970.00



PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.

PD184352 (CI-1040)




顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A10212
Mechanism of action Inhibitor
分子量 478.7
化学分子式 C17H14ClF2IN2O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 212631-79-3
Synonyms CI-1040
SMILES code C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl
化学名称 2-(2-Chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide


PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.
MEK1 (Cell-free assay) MEK2 (Cell-free assay)
17 nM17 nM


Solubility (25°C) * In vitro DMSO 96 mg/mL (200.55 mM)
Water <1 mg/mL (<1 mM)
Ethanol 14 mg/mL (29.24 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol, pH 9 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.89 mL 104.45 mL 208.9mL
0.5 mM 4.18 mL 20.89 mL 41.78 mL
1 mM 2.09 mL 10.44 mL 20.89 mL
5 mM 0.42 mL 2.09 mL 4.18 mL

*The above data is based on the productmolecular weight 478.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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