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PD98059

MEK 抑制剂

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产品目录号: A10705

库存状态:中国现货中国现货

产品名 目录号 价格 数量
PD98059 10mg A10705-10
¥ 500.00
PD98059 50mg A10705-50
¥ 1,100.00
PD98059 100mg A10705-100
¥ 1,900.00
PD98059 200mg A10705-200
¥ 3,500.00
PD98059 10mM * 1mL in DMSO A10705-10mM-D
¥ 550.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase.

PD98059

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 PD98059 发表的文献 (3)
  • Tsai CC, .et al. Protease-activated receptor 2 induces migration and promotes Slug-mediated epithelial-mesenchymal transition in lung adenocarcinoma cells, Biochim Biophys Acta Mol Cell Res, 2018, Oct 13. pii: S0167-4889(18)30452-X PMID: 30321617
  • Kim MH, .et al. C16?ceramide and sphingosine 1?phosphate/S1PR2 have opposite effects on cell growth through mTOR signaling pathway regulation, Oncol Rep, 2018, Nov;40(5):2977-2987 PMID: 30226616
  • Onozato D, .et al. Efficient Generation of Cynomolgus Monkey Induced Pluripotent Stem Cell-Derived Intestinal Organoids with Pharmacokinetic Functions, Stem Cells Dev, 2018, Aug 1;27(15):1033-1045 PMID: 29742964

Chemical Information

目录号 A10705
Mechanism of action Inhibitor
分子量 267.3
化学分子式 C16H13NO3
Solubility DMSO>32mg/mL Water<1mg/mL Ethanol>3mg/mL
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 167869-21-8
Synonyms N/A
SMILES code COC1=CC=CC(=C1N)C2=CC(=O)C3=CC=CC=C3O2
化学名称 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one

生物活性

Description
PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase.
Targets
MEK1 (Cell-free assay)
2 μM

溶解性

Solubility (25°C) * In vitro DMSO 14 mg/mL heating (52.37 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 37.41 mL 187.06 mL 374.11mL
0.5 mM 7.48 mL 37.41 mL 74.82 mL
1 mM 3.74 mL 18.71 mL 37.41 mL
5 mM 0.75 mL 3.74 mL 7.48 mL

*The above data is based on the productmolecular weight 267.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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